{"id":1682,"date":"2022-02-08T00:00:00","date_gmt":"2022-02-08T05:00:00","guid":{"rendered":"https:\/\/icesontario.wpengine.com\/journal-articles\/association-of-diabetes-duration-and-glycemic-control-with-stroke-rate-in-patients-with-atrial-fibrillation-and-diabetes-a-population-based-cohort-study\/"},"modified":"2023-06-14T19:43:34","modified_gmt":"2023-06-14T23:43:34","slug":"association-of-diabetes-duration-and-glycemic-control-with-stroke-rate-in-patients-with-atrial-fibrillation-and-diabetes-a-population-based-cohort-study","status":"publish","type":"journal_article","link":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/association-of-diabetes-duration-and-glycemic-control-with-stroke-rate-in-patients-with-atrial-fibrillation-and-diabetes-a-population-based-cohort-study\/","title":{"rendered":"Association of diabetes duration and glycemic control with stroke rate in patients with atrial fibrillation and diabetes: a population-based cohort study"},"content":{"rendered":"<p><strong>Background<\/strong> &#x2014; There are limited data on the association of diabetes duration and glycemic control with stroke risk in atrial fibrillation (AF). Our objective was to study the association of diabetes duration and glycated hemoglobin (HbA1c) with the rate of stroke in people with diabetes and newly diagnosed AF.<\/p>\n<p><span class=\"bold\">Methods and Results<\/span> &#x2014; This was a population&#x2010;based cohort study using linked administrative data sets. We studied 37 209 individuals aged &#x2265;66 years diagnosed with AF in Ontario between April 2009 and March 2019, who had diabetes diagnosed 1 to 16 years beforehand. The primary outcome was hospitalization for stroke at 1 year. Cause&#x2010;specific hazard regression was used to model the association of diabetes duration and glycated hemoglobin (HbA1c) with the rate of stroke. Restricted cubic spline analyses showed increasing hazard ratios (HR) for stroke with longer diabetes duration that plateaued after 10 years and increasing HRs for stroke with HbA1c levels &gt;7%. Relative to patients with &lt;5 years diabetes duration, stroke rates were significantly higher for patients with &#x2265;10 years duration (HR, 1.45; 95% CI, 1.16&#x2013;1.82; <em>P<\/em>=0.001), while diabetes duration 5 to &lt;10 years was not significantly different. Relative to glycated hemoglobin 6% to &lt;7%, values &#x2265;8% were associated with higher stroke rates (HR, 1.44; 95% CI, 1.12&#x2013;1.84; <em>P<\/em>=0.004), while other HbA1c categories were not significantly different.<\/p>\n<p><strong>Conclusions<\/strong> &#x2014; Longer diabetes duration and higher glycated hemoglobin were associated with significantly higher stroke rates in patients with AF and diabetes. Models for stroke risk prediction and preventive care in AF may be improved by considering patients&#x2019; diabetes characteristics.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Background &#x2014; There are limited data on the association of diabetes duration and glycemic control with stroke risk in atrial fibrillation (AF). Our objective was to study the association of diabetes duration and glycated hemoglobin (HbA1c) with the rate of stroke in people with diabetes and newly diagnosed AF. Methods and Results &#x2014; This was [&hellip;]<\/p>\n","protected":false},"template":"","migration-helper-automated":[],"migration-manual":[],"topic":[],"migration-helper-qa-sample-set":[],"class_list":["post-1682","journal_article","type-journal_article","status-publish","hentry"],"acf":{"citation":"Abdel-Qadir H, Gunn M, Lega IC, Pang A, Austin PC, Singh SM, Jackevicius CA, Tu K, Dorian P, Lee DS, Ko DT. <em>J Am Heart Assoc<\/em>. 2022; 11(4):e023643. Epub 2022 Feb 8.","source_url":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.121.023643","ices_scientist":[1379,1285,1385,1281,1290,1146],"site":[6733],"research_program":[6742],"news_release":[],"journal_article":[],"atlas":[],"research_report":[],"infographic":[],"video":[],"downloads":null,"links":null,"sitecore_item_id":"A17D7D24-A10C-4F67-962C-745DF6CF5FBF","sitecore_item_name":"Association-of-diabetes-duration-and-glycemic-control-with-stroke-rate-in-patients","sitecore_field_values":"{\n  \"Title\": \"Association of diabetes duration and glycemic control with stroke rate in patients with atrial fibrillation and diabetes: a population-based cohort study\",\n  \"Short title\": \"Association of diabetes duration and\",\n  \"Summary\": \"This study found that longer diabetes duration and higher glycated hemoglobin were associated with significantly higher stroke rates in patients with atrial fibrillation and diabetes.\",\n  \"Citation\": \"<p>Abdel-Qadir H, Gunn M, Lega IC, Pang A, Austin PC, Singh SM, Jackevicius CA, Tu K, Dorian P, Lee DS, Ko DT. <em>J Am Heart Assoc<\/em>. 2022; 11(4):e023643. Epub 2022 Feb 8. DOI: <a href=\"https:\/\/doi.org\/10.1161\/JAHA.121.023643\" title=\"opens external link\">https:\/\/doi.org\/10.1161\/JAHA.121.023643<\/a><\/p>\",\n  \"Abstract\": \"<p><strong>Background<\/strong> &mdash; There are limited data on the association of diabetes duration and glycemic control with stroke risk in atrial fibrillation (AF). Our objective was to study the association of diabetes duration and glycated hemoglobin (HbA1c) with the rate of stroke in people with diabetes and newly diagnosed AF.<\/p>n<p><span class=\"bold\">Methods and Results<\/span> &mdash; This was a population\u2010based cohort study using linked administrative data sets. We studied 37 209 individuals aged &ge;66 years diagnosed with AF in Ontario between April 2009 and March 2019, who had diabetes diagnosed 1 to 16 years beforehand. The primary outcome was hospitalization for stroke at 1 year. Cause\u2010specific hazard regression was used to model the association of diabetes duration and glycated hemoglobin (HbA1c) with the rate of stroke. Restricted cubic spline analyses showed increasing hazard ratios (HR) for stroke with longer diabetes duration that plateaued after 10 years and increasing HRs for stroke with HbA1c levels &gt;7%. Relative to patients with &lt;5 years diabetes duration, stroke rates were significantly higher for patients with &ge;10 years duration (HR, 1.45; 95% CI, 1.16&ndash;1.82; <em>P<\/em>=0.001), while diabetes duration 5 to &lt;10 years was not significantly different. Relative to glycated hemoglobin 6% to &lt;7%, values &ge;8% were associated with higher stroke rates (HR, 1.44; 95% CI, 1.12&ndash;1.84; <em>P<\/em>=0.004), while other HbA1c categories were not significantly different.<\/p>n<p><strong>Conclusions<\/strong> &mdash; Longer diabetes duration and higher glycated hemoglobin were associated with significantly higher stroke rates in patients with AF and diabetes. Models for stroke risk prediction and preventive care in AF may be improved by considering patients&rsquo; diabetes characteristics.<\/p>n<p><a href=\"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.121.023643\" title=\"opens external link\">View full text<\/a><\/p>\",\n  \"Research Programs\": \"{BEC72DE0-BA8C-42B8-ACE5-EE29FFB2CB3B}\",\n  \"ICES Locations\": \"{4FCAABBA-14A5-42E6-8F33-BC6C2F1D9908}\",\n  \"ICES Scientists\": \"{B970C3FF-436A-4021-8541-FB5724A3D343}|{A3F02DC0-F8AB-4534-90F5-16B3339AA3D0}|{7D498E8B-5801-4F9E-AC41-11ED50F3C34E}|{BA86E62A-3468-443D-939F-34A9EFA7B7AA}|{CEEE13AD-C7DE-455F-ACF8-AAD7D27BB178}|{B3827152-93D1-4FB2-B106-590CB331A264}\",\n  \"Posted Date\": \"20220208T000000\",\n  \"Show on Publications Landing Page\": \"1\"\n}","previous_url":"https:\/\/www.ices.on.ca\/Publications\/Journal-Articles\/2022\/February\/Association-of-diabetes-duration-and-glycemic-control-with-stroke-rate-in-patients"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>ICES | Association of diabetes duration and glycemic control with stroke rate in patients with atrial fibrillation and diabetes: a population-based cohort study<\/title>\n<meta name=\"description\" content=\"Background &#x2014; There are limited data on the association of diabetes duration and glycemic control with stroke risk in atrial fibrillation (AF). Our\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/association-of-diabetes-duration-and-glycemic-control-with-stroke-rate-in-patients-with-atrial-fibrillation-and-diabetes-a-population-based-cohort-study\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"ICES | Association of diabetes duration and glycemic control with stroke rate in patients with atrial fibrillation and diabetes: a population-based cohort study\" \/>\n<meta property=\"og:description\" content=\"Background &#x2014; There are limited data on the association of diabetes duration and glycemic control with stroke risk in atrial fibrillation (AF). 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