{"id":16696,"date":"2023-08-31T10:50:00","date_gmt":"2023-08-31T14:50:00","guid":{"rendered":"https:\/\/www.ices.on.ca\/?post_type=journal_article&#038;p=16696"},"modified":"2023-09-06T10:58:17","modified_gmt":"2023-09-06T14:58:17","slug":"sars-cov-2-infection-hospitalization-and-mortality-in-adults-with-and-without-cancer","status":"publish","type":"journal_article","link":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/sars-cov-2-infection-hospitalization-and-mortality-in-adults-with-and-without-cancer\/","title":{"rendered":"SARS-CoV-2 infection, hospitalization, and mortality in adults with and without cancer"},"content":{"rendered":"<p><strong>Importance<\/strong> \u2014 Patients with cancer are at increased risk of SARS-CoV-2\u2013associated adverse outcomes.<\/p>\n<p><strong>Objective<\/strong> \u2014 To determine the associations of tumor type with SARS-CoV-2 infection, hospitalization, intensive care unit (ICU) admission, and death.<\/p>\n<p><strong>Design, Setting, and Participants<\/strong> \u2014 This retrospective, population-based cohort study included community-dwelling adults aged at least 18 years in Ontario, Canada, ICES-linked provincial health databases from January 1, 2020, to November 30, 2021. Data were analyzed from December 1, 2021, to November 1, 2022.<\/p>\n<p><strong>Exposures<\/strong> \u2014 Cancer diagnosis.<\/p>\n<p><strong>Main Outcomes and Measures<\/strong> \u2014 The primary outcome was SARS-CoV-2 infection, and secondary outcomes included all-cause 14-day hospitalization, 21-day ICU admission, and 28-day death following SARS-CoV-2 infection. Cox proportional hazards models were used to obtain adjusted hazard ratios (aHRs) and 95% CIs.<\/p>\n<p><strong>Results<\/strong> \u2014 Of 11\u202f732\u202f108 people in the ICES-linked health databases, 279\u202f287 had cancer (57.2% female; mean [SD] age, 65.9 [16.1] years) and 11\u202f452\u202f821 people did not have cancer (45.7% female; mean [SD] age, 65.9 [16.0] years). Overall, 464\u202f574 individuals (4.1%) developed SARS-CoV-2 infection. Individuals with hematologic malignant neoplasms (33\u202f901 individuals) were at increased risk of SARS-CoV-2 infection (aHR, 1.19; 95% CI, 1.13-1.25), 14-day hospitalization (aHR, 1.75; 95% CI, 1.57-1.96), and 28-day mortality (aHR, 2.03; 95% CI, 1.74-2.38) compared with the overall population, while individuals with solid tumors (245\u202f386 individuals) were at lower risk of SARS-CoV-2 infection (aHR, 0.93; 95% CI, 0.91-0.95) but increased risk of 14-day hospitalization (aHR, 1.11; 95% CI, 1.05-1.18) and 28-day mortality (aHR, 1.31; 95% CI, 1.19-1.44). The 28-day mortality rate was high in hospitalized patients with hematologic malignant neoplasms (163 of 321 hospitalized patients [50.7%]) or solid tumors (486 of 1060 hospitalized patients [45.8%]). However, the risk of 21-day ICU admission in patients with hematologic malignant neoplasms (aHR, 1.14; 95% CI, 0.93-1.40) or solid tumors (aHR, 0.93; 95% CI, 0.82-1.05) was not significantly different from that among individuals without cancer. The SARS-CoV-2 infection risk decreased stepwise with increasing numbers of COVID-19 vaccine doses received (1 dose: aHR, 0.63; 95% CI, 0.62-0.63; 2 doses: aHR, 0.16; 95% CI, 0.16-0.16; 3 doses: aHR, 0.05; 95% CI, 0.04-0.06).<\/p>\n<p><strong>Conclusions and Relevance<\/strong> \u2014 These findings highlight the importance of prioritization strategies regarding ICU access to reduce the mortality risk in increased-risk populations, such as patients with cancer.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Importance \u2014 Patients with cancer are at increased risk of SARS-CoV-2\u2013associated adverse outcomes. Objective \u2014 To determine the associations of tumor type with SARS-CoV-2 infection, hospitalization, intensive care unit (ICU) admission, and death. Design, Setting, and Participants \u2014 This retrospective, population-based cohort study included community-dwelling adults aged at least 18 years in Ontario, Canada, ICES-linked [&hellip;]<\/p>\n","protected":false},"template":"","migration-helper-automated":[],"migration-manual":[],"topic":[24,38,39],"migration-helper-qa-sample-set":[],"class_list":["post-16696","journal_article","type-journal_article","status-publish","hentry","topic-acute-and-emergency-services","topic-cancer-and-cancer-screening","topic-infectious-diseases"],"acf":{"citation":"Hosseini-Moghaddam SM, Shepherd FA, Swayze S, Kwong JC, Chan KKW. <em>JAMA Netw Open<\/em>. 2023; 6(8):e2331617. Epub 2023 Aug 31.","source_url":"https:\/\/doi.org\/10.1001\/jamanetworkopen.2023.31617","ices_scientist":[1259,1149,1185],"site":[6733],"research_program":[6745],"news_release":"","journal_article":"","atlas":"","research_report":"","infographic":"","video":"","downloads":null,"links":null,"sitecore_item_id":"","sitecore_item_name":"","sitecore_field_values":"","previous_url":""},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>ICES | SARS-CoV-2 infection, hospitalization, and mortality in adults with and without cancer<\/title>\n<meta name=\"description\" content=\"Importance \u2014 Patients with cancer are at increased risk of SARS-CoV-2\u2013associated adverse outcomes. 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