{"id":16673,"date":"2023-08-30T10:00:00","date_gmt":"2023-08-30T14:00:00","guid":{"rendered":"https:\/\/www.ices.on.ca\/?post_type=journal_article&#038;p=16673"},"modified":"2023-08-30T10:22:06","modified_gmt":"2023-08-30T14:22:06","slug":"stroke-risk-in-women-with-atrial-fibrillation","status":"publish","type":"journal_article","link":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/stroke-risk-in-women-with-atrial-fibrillation\/","title":{"rendered":"Stroke risk in women with atrial fibrillation"},"content":{"rendered":"<p><strong>Background and Aims<\/strong> \u2014 Female sex is associated with higher rates of stroke in atrial fibrillation (AF) after adjustment for other CHA2DS2-VASc factors. This study aimed to describe sex differences in age and cardiovascular care to examine their relationship with stroke hazard in AF.<\/p>\n<p><strong>Methods<\/strong> \u2014 Population-based cohort study using administrative datasets of people aged &gt;65 years diagnosed with AF in Ontario between 2007 and 2019. Cause-specific hazard regression was used to estimate the adjusted hazard ratio (HR) for stroke associated with female sex over a 2-year follow-up. Model 1 included CHA2DS2-VASc factors, with age modelled as 66\u201374 vs. \u2265 75 years. Model 2 treated age as a continuous variable and included an age\u2013sex interaction term. Model 3 further accounted for multimorbidity and markers of cardiovascular care.<\/p>\n<p><strong>Results<\/strong> \u2014 The cohort consisted of 354 254 individuals with AF (median age 78 years, 49.2% female). Females were more likely to be diagnosed in emergency departments and less likely to receive cardiologist assessments, statins, or LDL-C testing, with higher LDL-C levels among females than males. In Model 1, the adjusted HR for stroke associated with female sex was 1.27 (95% confidence interval 1.21\u20131.32). Model 2 revealed a significant age\u2013sex interaction, such that female sex was only associated with increased stroke hazard at age &gt;70 years. Adjusting for markers of cardiovascular care and multimorbidity further decreased the HR, so that female sex was not associated with increased stroke hazard at age \u226480 years.<\/p>\n<p><strong>Conclusion<\/strong> \u2014 Older age and inequities in cardiovascular care may partly explain higher stroke rates in females with AF.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Background and Aims \u2014 Female sex is associated with higher rates of stroke in atrial fibrillation (AF) after adjustment for other CHA2DS2-VASc factors. This study aimed to describe sex differences in age and cardiovascular care to examine their relationship with stroke hazard in AF. Methods \u2014 Population-based cohort study using administrative datasets of people aged [&hellip;]<\/p>\n","protected":false},"template":"","migration-helper-automated":[],"migration-manual":[],"topic":[40,62,21],"migration-helper-qa-sample-set":[],"class_list":["post-16673","journal_article","type-journal_article","status-publish","hentry","topic-cardiovascular-disease","topic-health-services-research","topic-women-or-gender-based-research"],"acf":{"citation":"Buhari H, Fang J, Han L, Austin PC, Dorian P, Jackevicius CA, Yu AYX, Kapral MK, Singh SM, Tu K, Ko DT, Atzema CL, Benjamin EJ, Lee DS, Abdel-Qadir H. <em>Eur Heart J.\u00a0<\/em>2023; Aug 30 [Epub ahead of print].","source_url":"https:\/\/doi.org\/10.1093\/eurheartj\/ehad508","ices_scientist":[1385,1298,1150,1146,1383,1290,1379],"site":[6733],"research_program":[6742],"news_release":[16674],"journal_article":"","atlas":"","research_report":"","infographic":[16675],"video":"","downloads":null,"links":null,"sitecore_item_id":"","sitecore_item_name":"","sitecore_field_values":"","previous_url":""},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>ICES | Stroke risk in women with atrial fibrillation<\/title>\n<meta name=\"description\" content=\"Background and Aims \u2014 Female sex is associated with higher rates of stroke in atrial fibrillation (AF) after adjustment for other CHA2DS2-VASc factors.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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