{"id":1663,"date":"2022-01-11T00:00:00","date_gmt":"2022-01-11T05:00:00","guid":{"rendered":"https:\/\/icesontario.wpengine.com\/journal-articles\/analysis-of-platelet-count-and-new-cancer-diagnosis-over-a-10-year-period\/"},"modified":"2023-06-14T19:48:53","modified_gmt":"2023-06-14T23:48:53","slug":"analysis-of-platelet-count-and-new-cancer-diagnosis-over-a-10-year-period","status":"publish","type":"journal_article","link":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/analysis-of-platelet-count-and-new-cancer-diagnosis-over-a-10-year-period\/","title":{"rendered":"Analysis of platelet count and new cancer diagnosis over a 10-year period"},"content":{"rendered":"<p><strong>Importance<\/strong> &#x2014; Individuals with cancer often have an elevated platelet count at the time of diagnosis. The extent to which an elevated platelet count is an indicator of cancer is unclear.<\/p>\n<p><strong>Objective<\/strong> &#x2014; To evaluate the association of an elevated platelet count with a cancer diagnosis.<\/p>\n<p><span class=\"bold\">Design, Setting, and Participants<\/span> &#x2014; This nested case-control study included Ontario residents enrolled in the provincial health insurance plan who had 1 or more routine complete blood count (CBC) tests performed between January 1, 2007, and December 31, 2017, with follow-up through December 31, 2018. Case patients were individuals with a new cancer diagnosis during the observation period. Eligible control individuals were cancer free before the date of diagnosis for a case patient to whom they were matched. One case patient was matched to 3 controls based on sex, age, and healthcare use patterns. Data were analyzed from September 24, 2020, to July 13, 2021.<\/p>\n<p><strong>Exposures<\/strong> &#x2014; Case patients and controls were assigned to 1 of 5 exposure groups based on age- and sex-specific platelet count distributions in the control population: very low (&#x2264;10th percentile), low (&gt;10th to 25th percentile), medium (&gt;25th to &lt;75th percentile), high (75th to &lt;90th percentile), and very high (&#x2265;90th percentile).<\/p>\n<p><span class=\"bold\">Main Outcomes and Measures<\/span> &#x2014; Odds ratios (ORs) were estimated for specific cancer sites for each category of platelet count at intervals up to 10 years after a blood test.<\/p>\n<p><strong>Results<\/strong> &#x2014; Of the 8 917 187 eligible Ontario residents with a routine CBC record available, 4 971 578 (55.8%) were women; the median age at the first CBC was 46.4 years (IQR, 32.5-59.5 years). Among individuals with a routine CBC record available, 495 341 (5.6%) received a diagnosis of first primary cancer during the 10-year observation period. The OR for a solid tumor diagnosis associated with a very high platelet count vs a medium platelet count in the 6-month period before the diagnosis was 2.32 (95% CI, 2.28-2.35). A very high platelet count was associated with colon (OR, 4.38; 95% CI, 4.22-4.54), lung (OR, 4.37; 95% CI, 4.22-4.53), ovarian (OR, 4.62; 95% CI, 4.19-5.09), and stomach (OR, 4.27; 95% CI, 3.91-4.66) cancers. Odds ratios attenuated with increasing time from CBC test to cancer diagnosis.<\/p>\n<p><span class=\"bold\">Conclusions and Relevance<\/span> &#x2014; In this nested case-control study, an elevated platelet count was associated with increased risk of cancer at several sites. Our findings suggest that an elevated platelet count could potentially serve as a marker for the presence of some cancer types.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Importance &#x2014; Individuals with cancer often have an elevated platelet count at the time of diagnosis. The extent to which an elevated platelet count is an indicator of cancer is unclear. Objective &#x2014; To evaluate the association of an elevated platelet count with a cancer diagnosis. Design, Setting, and Participants &#x2014; This nested case-control study [&hellip;]<\/p>\n","protected":false},"template":"","migration-helper-automated":[],"migration-manual":[],"topic":[],"migration-helper-qa-sample-set":[],"class_list":["post-1663","journal_article","type-journal_article","status-publish","hentry"],"acf":{"citation":"Giannakeas V, Kotsopoulos J, Cheung MC, Rosella L, Brooks JD, Lipscombe L, Akbari MR, Austin PC, Narod SA. <em>JAMA Netw Open<\/em>. 2022; 5(1):e2141633. Epub 2022 Jan 11.","source_url":"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/fullarticle\/2787932","ices_scientist":[1295,1193,1339,1385,23247],"site":[6735],"research_program":[6741],"news_release":[],"journal_article":[],"atlas":[],"research_report":[],"infographic":[],"video":[],"downloads":null,"links":null,"sitecore_item_id":"96CF39E3-1D21-4E6F-BF39-8CAE6A1835DF","sitecore_item_name":"Analysis-of-platelet-count-and-new-cancer-diagnosis-over-a-10-year-period","sitecore_field_values":"{\n  \"Title\": \"Analysis of platelet count and new cancer diagnosis over a 10-year period\",\n  \"Short title\": \"Analysis of platelet count and new\",\n  \"Summary\": \"The study objective was to evaluate the association of an elevated platelet count with a cancer diagnosis.\",\n  \"Citation\": \"<p>Giannakeas V, Kotsopoulos J, Cheung MC, Rosella L, Brooks JD, Lipscombe L, Akbari MR, Austin PC, Narod SA. <em>JAMA Netw Open<\/em>. 2022; 5(1):e2141633. Epub 2022 Jan 11. DOI: <a href=\"https:\/\/doi.org\/10.1001\/jamanetworkopen.2021.41633\" title=\"opens external link\">https:\/\/doi.org\/10.1001\/jamanetworkopen.2021.41633<\/a><\/p>\",\n  \"Abstract\": \"<p><strong>Importance<\/strong> &mdash; Individuals with cancer often have an elevated platelet count at the time of diagnosis. The extent to which an elevated platelet count is an indicator of cancer is unclear.<\/p>n<p><strong>Objective<\/strong> &mdash; To evaluate the association of an elevated platelet count with a cancer diagnosis.<\/p>n<p><span class=\"bold\">Design, Setting, and Participants<\/span> &mdash; This nested case-control study included Ontario residents enrolled in the provincial health insurance plan who had 1 or more routine complete blood count (CBC) tests performed between January 1, 2007, and December 31, 2017, with follow-up through December 31, 2018. Case patients were individuals with a new cancer diagnosis during the observation period. Eligible control individuals were cancer free before the date of diagnosis for a case patient to whom they were matched. One case patient was matched to 3 controls based on sex, age, and healthcare use patterns. Data were analyzed from September 24, 2020, to July 13, 2021.<\/p>n<p><strong>Exposures<\/strong> &mdash; Case patients and controls were assigned to 1 of 5 exposure groups based on age- and sex-specific platelet count distributions in the control population: very low (&le;10th percentile), low (&gt;10th to 25th percentile), medium (&gt;25th to &lt;75th percentile), high (75th to &lt;90th percentile), and very high (&ge;90th percentile).<\/p>n<p><span class=\"bold\">Main Outcomes and Measures<\/span> &mdash; Odds ratios (ORs) were estimated for specific cancer sites for each category of platelet count at intervals up to 10 years after a blood test.<\/p>n<p><strong>Results<\/strong> &mdash; Of the 8 917 187 eligible Ontario residents with a routine CBC record available, 4 971 578 (55.8%) were women; the median age at the first CBC was 46.4 years (IQR, 32.5-59.5 years). Among individuals with a routine CBC record available, 495 341 (5.6%) received a diagnosis of first primary cancer during the 10-year observation period. The OR for a solid tumor diagnosis associated with a very high platelet count vs a medium platelet count in the 6-month period before the diagnosis was 2.32 (95% CI, 2.28-2.35). A very high platelet count was associated with colon (OR, 4.38; 95% CI, 4.22-4.54), lung (OR, 4.37; 95% CI, 4.22-4.53), ovarian (OR, 4.62; 95% CI, 4.19-5.09), and stomach (OR, 4.27; 95% CI, 3.91-4.66) cancers. Odds ratios attenuated with increasing time from CBC test to cancer diagnosis.<\/p>n<p><span class=\"bold\">Conclusions and Relevance<\/span> &mdash; In this nested case-control study, an elevated platelet count was associated with increased risk of cancer at several sites. Our findings suggest that an elevated platelet count could potentially serve as a marker for the presence of some cancer types.<\/p>n<p><a href=\"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/fullarticle\/2787932\" title=\"opens external link\">View full text<\/a><\/p>\",\n  \"Research Programs\": \"{85DE96A6-4C96-40C7-8E6D-7597A0EB5F80}\",\n  \"ICES Locations\": \"{FBE2D1B1-C0BA-423F-8D16-39466B6C1424}\",\n  \"ICES Scientists\": \"{DC2C9ADE-ED70-4834-A8AC-A7271C6E48F5}|{C61EC381-DBA1-4E07-8583-0E6F2F691360}|{430B2731-D3D6-4D57-9AF4-AA7626CF61B0}|{7D498E8B-5801-4F9E-AC41-11ED50F3C34E}\",\n  \"Posted Date\": \"20220111T000000\",\n  \"Show on Publications Landing Page\": \"1\"\n}","previous_url":"https:\/\/www.ices.on.ca\/Publications\/Journal-Articles\/2022\/January\/Analysis-of-platelet-count-and-new-cancer-diagnosis-over-a-10-year-period"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.0 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>ICES | Analysis of platelet count and new cancer diagnosis over a 10-year period<\/title>\n<meta name=\"description\" content=\"Importance &#x2014; Individuals with cancer often have an elevated platelet count at the time of diagnosis. 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