{"id":16171,"date":"2023-06-22T15:41:37","date_gmt":"2023-06-22T19:41:37","guid":{"rendered":"https:\/\/www.ices.on.ca\/?post_type=journal_article&#038;p=16171"},"modified":"2023-07-24T15:55:38","modified_gmt":"2023-07-24T19:55:38","slug":"healthcare-costs-and-outcomes-associated-with-laboratory-confirmed-lyme-disease-in-ontario-canada","status":"publish","type":"journal_article","link":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/healthcare-costs-and-outcomes-associated-with-laboratory-confirmed-lyme-disease-in-ontario-canada\/","title":{"rendered":"Healthcare costs and outcomes associated with laboratory-confirmed Lyme disease in Ontario, Canada: a population-based cohort study"},"content":{"rendered":"<p><strong>Background<\/strong> &#8211; The objective of this study was to estimate the economic burden attributable to laboratory-confirmed Lyme disease (LD) in Ontario, Canada and assess health outcomes associated with LD.<\/p>\n<p><strong>Method<\/strong> &#8211; We conducted a cohort study using laboratory-confirmed LD cases accrued between 2006 and 2018. The exposed cohort was matched 1:3 to the unexposed cohort using a combination of hard and propensity score matching. We used phase-of-care costing methods to calculate attributable costs for four phases of illness: pre-diagnosis, acute care, post-acute care, and continuing care in 2018 Canadian dollars. We used ICD-10-CA and OHIP billing codes to identify emergency department visits, physician billings and hospitalizations related to LD sequelae to assess health outcomes.<\/p>\n<p><strong>Results<\/strong> &#8211; A total of 2,808 cases were identified with a mean age of 46.5 (20.7) years and 44% female. Within 30-days, 404 (14.3%) cases required an ED visit and 63 (2.4%) cases required hospitalization. The mean (95% CI) total costs for LD cases in pre-diagnosis, acute, and post-acute care phases were $209 ($181, 238), $1,084 ($956, $1,212), and $1,714 ($1,499, $1,927), respectively. The highest mean attributable 10-day cost was $275 ($231, $319) during acute care. At 1-year post-infection, LD increased the relative risk of nerve palsies by 62 (20, 197), and polyneuropathy by 24 (3.0, 190). LD resulted in 16 Lyme meningitis events vs. 0 events in the unexposed.<\/p>\n<p><strong>Conclusion<\/strong> &#8211; Individuals with laboratory-confirmed LD have increased healthcare resource use pre-diagnosis and up to six months post-diagnosis, and were more likely to seek healthcare services related to LD sequelae.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Background &#8211; The objective of this study was to estimate the economic burden attributable to laboratory-confirmed Lyme disease (LD) in Ontario, Canada and assess health outcomes associated with LD. Method &#8211; We conducted a cohort study using laboratory-confirmed LD cases accrued between 2006 and 2018. The exposed cohort was matched 1:3 to the unexposed cohort [&hellip;]<\/p>\n","protected":false},"template":"","migration-helper-automated":[],"migration-manual":[],"topic":[39,46],"migration-helper-qa-sample-set":[],"class_list":["post-16171","journal_article","type-journal_article","status-publish","hentry","topic-infectious-diseases","topic-internal-medicine"],"acf":{"citation":"Mac S, Evans G, Pullenayegum E, N. Patel SN, Sander B. <em>PLoS One<\/em>. 2023; 18(6):e0286552. Epub 2023 Jun 22.","source_url":"https:\/\/journals.plos.org\/plosone\/article?id=10.1371\/journal.pone.0286552","ices_scientist":[1362,1226],"site":[6733],"research_program":[6747],"news_release":"","journal_article":"","atlas":"","research_report":"","infographic":"","video":"","downloads":null,"links":null,"sitecore_item_id":"","sitecore_item_name":"","sitecore_field_values":"","previous_url":""},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>ICES | Healthcare costs and outcomes associated with laboratory-confirmed Lyme disease in Ontario, Canada: a population-based cohort study<\/title>\n<meta name=\"description\" content=\"Background - The objective of this study was to estimate the economic burden attributable to laboratory-confirmed Lyme disease (LD) in Ontario, Canada and\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/healthcare-costs-and-outcomes-associated-with-laboratory-confirmed-lyme-disease-in-ontario-canada\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"ICES | Healthcare costs and outcomes associated with laboratory-confirmed Lyme disease in Ontario, Canada: a population-based cohort study\" \/>\n<meta property=\"og:description\" content=\"Background - 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