{"id":16155,"date":"2023-06-23T08:15:58","date_gmt":"2023-06-23T12:15:58","guid":{"rendered":"https:\/\/www.ices.on.ca\/?post_type=journal_article&#038;p=16155"},"modified":"2023-07-24T15:52:42","modified_gmt":"2023-07-24T19:52:42","slug":"associations-between-modest-reductions-in-kidney-function-and-adverse-outcomes-in-young-adults","status":"publish","type":"journal_article","link":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/associations-between-modest-reductions-in-kidney-function-and-adverse-outcomes-in-young-adults\/","title":{"rendered":"Associations between modest reductions in kidney function and adverse outcomes in young adults: retrospective, population based cohort study"},"content":{"rendered":"<p><strong>Objective<\/strong> \u2014 To study age specific associations of modest reductions in estimated glomerular filtration rate (eGFR) with adverse outcomes.<\/p>\n<p><strong>Design<\/strong> \u2014 Retrospective, population based cohort study.<\/p>\n<p><strong>Setting<\/strong> \u2014 Linked healthcare administrative datasets in Ontario, Canada.<\/p>\n<p><strong>Participants<\/strong> \u2014 Adult residents (18-65 years) with at least one outpatient eGFR value (categorized in 10 unit increments from 50 mL\/min\/1.73m<sup>2<\/sup> to &gt;120 mL\/min\/1.73m<sup>2<\/sup>), with no history of kidney disease.<\/p>\n<p><strong>Main Outcome Measures<\/strong> \u2014 eGFRs and hazard ratios of composite adverse outcome (all cause mortality, any cardiovascular event, and kidney failure) stratified by age (18-39 years, 40-49 years, and 50-65 years), and relative to age specific eGFR referents (100-110 mL\/min\/1.73m<sup>2<\/sup>) for ages 18-39 years, 90-100 for 40-49 years, 80-90 for 50-65 years).<\/p>\n<p><strong>Results<\/strong> \u2014 From 1 January 2008 to 31 March 2021, among 8 703 871 adults (mean age 41.3 (standard deviation 13.6) years; mean index eGFR 104.2 mL\/min\/1.73m<sup>2<\/sup> (standard deviation 16.1); median follow-up 9.2 years (interquartile range 5.7-11.4)), modestly reduced eGFR measurements specific to age were recorded in 18.0% of those aged 18-39, 18.8% in those aged 40-49, and 17.0% in those aged 50-65. In comparison with age specific referents, adverse outcomes were consistently higher by hazard ratio and incidence for ages 18-39 compared with older groups across all eGFR categories. For modest reductions (eGFR 70-80 mL\/min\/1.73m<sup>2<\/sup>), the hazard ratio for ages 18-39 years was 1.42 (95% confidence interval 1.35 to 1.49), 4.39 per 1000 person years; for ages 40-49 years was 1.13 (1.10 to 1.16), 9.61 per 1000 person years; and for ages 50-65 years was 1.08 (1.07 to 1.09), 23.4 per 1000 person years. Results persisted for each individual outcome and in many sensitivity analyses.<\/p>\n<p><strong>Conclusions<\/strong> \u2014 Modest eGFR reductions were consistently associated with higher rates of adverse outcomes. Higher relative hazards were most prominent and occurred as early as eGFR &lt;80 mL\/min\/1.73m<sup>2<\/sup> in younger adults, compared with older groups. These findings suggest a role for more frequent monitoring of kidney function in younger adults to identify individuals at risk to prevent chronic kidney disease and its complications.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Objective \u2014 To study age specific associations of modest reductions in estimated glomerular filtration rate (eGFR) with adverse outcomes. Design \u2014 Retrospective, population based cohort study. Setting \u2014 Linked healthcare administrative datasets in Ontario, Canada. Participants \u2014 Adult residents (18-65 years) with at least one outpatient eGFR value (categorized in 10 unit increments from 50 [&hellip;]<\/p>\n","protected":false},"template":"","migration-helper-automated":[],"migration-manual":[],"topic":[16,49],"migration-helper-qa-sample-set":[],"class_list":["post-16155","journal_article","type-journal_article","status-publish","hentry","topic-children-and-young-people","topic-kidney-disease"],"acf":{"citation":"Hussain J, Grubic N, Akbari A, Canney M, Elliott MJ, Ravani P, Tanuseputro P, Clark EG, Hundemer GL, Ramsay T, Tangri N, Knoll GA, Sood MM. <em>BMJ<\/em>. 2023; 381:e075062. Epub 2023 Jun 23.","source_url":"http:\/\/dx.doi.org\/10.1136\/bmj\u20112023\u2011075062","ices_scientist":[1107,1144,1264],"site":[6734],"research_program":[6743],"news_release":[16174],"journal_article":"","atlas":"","research_report":"","infographic":[16172],"video":"","downloads":null,"links":null,"sitecore_item_id":"","sitecore_item_name":"","sitecore_field_values":"","previous_url":""},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>ICES | Associations between modest reductions in kidney function and adverse outcomes in young adults: retrospective, population based cohort study<\/title>\n<meta name=\"description\" content=\"Objective \u2014 To study age specific associations of modest reductions in estimated glomerular filtration rate (eGFR) with adverse outcomes. Design \u2014\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/associations-between-modest-reductions-in-kidney-function-and-adverse-outcomes-in-young-adults\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"ICES | Associations between modest reductions in kidney function and adverse outcomes in young adults: retrospective, population based cohort study\" \/>\n<meta property=\"og:description\" content=\"Objective \u2014 To study age specific associations of modest reductions in estimated glomerular filtration rate (eGFR) with adverse outcomes. Design \u2014\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/associations-between-modest-reductions-in-kidney-function-and-adverse-outcomes-in-young-adults\/\" \/>\n<meta property=\"og:site_name\" content=\"ICES\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/ICESOntario\/\" \/>\n<meta property=\"article:modified_time\" content=\"2023-07-24T19:52:42+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.ices.on.ca\/wp-content\/uploads\/2024\/11\/ic-es-data-discovery-better-health-logo.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"675\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/publications\\\/journal-articles\\\/associations-between-modest-reductions-in-kidney-function-and-adverse-outcomes-in-young-adults\\\/\",\"url\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/publications\\\/journal-articles\\\/associations-between-modest-reductions-in-kidney-function-and-adverse-outcomes-in-young-adults\\\/\",\"name\":\"ICES | Associations between modest reductions in kidney function and adverse outcomes in young adults: retrospective, population based cohort study\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/#website\"},\"datePublished\":\"2023-06-23T12:15:58+00:00\",\"dateModified\":\"2023-07-24T19:52:42+00:00\",\"description\":\"Objective \u2014 To study age specific associations of modest reductions in estimated glomerular filtration rate (eGFR) with adverse outcomes. Design \u2014\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/publications\\\/journal-articles\\\/associations-between-modest-reductions-in-kidney-function-and-adverse-outcomes-in-young-adults\\\/#breadcrumb\"},\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/publications\\\/journal-articles\\\/associations-between-modest-reductions-in-kidney-function-and-adverse-outcomes-in-young-adults\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/publications\\\/journal-articles\\\/associations-between-modest-reductions-in-kidney-function-and-adverse-outcomes-in-young-adults\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Journal Articles\",\"item\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/publications\\\/journal-articles\\\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Associations between modest reductions in kidney function and adverse outcomes in young adults: retrospective, population based cohort study\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/#website\",\"url\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/\",\"name\":\"ICES\",\"description\":\"POPULATION-BASED HEALTH RESEARCH THAT MAKES A DIFFERENCE\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/#organization\"},\"alternateName\":\"Institute for Clinical Evaluative Sciences\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"fr-FR\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/#organization\",\"name\":\"ICES\",\"alternateName\":\"Institute for Clinical Evaluative Sciences\",\"url\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/www.ices.on.ca\\\/wp-content\\\/uploads\\\/2023\\\/04\\\/ices-logo.png\",\"contentUrl\":\"https:\\\/\\\/www.ices.on.ca\\\/wp-content\\\/uploads\\\/2023\\\/04\\\/ices-logo.png\",\"width\":\"676\",\"height\":\"618\",\"caption\":\"ICES\"},\"image\":{\"@id\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/www.facebook.com\\\/ICESOntario\\\/\",\"https:\\\/\\\/www.linkedin.com\\\/company\\\/ices-research-institute\\\/\"]}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"ICES | Associations between modest reductions in kidney function and adverse outcomes in young adults: retrospective, population based cohort study","description":"Objective \u2014 To study age specific associations of modest reductions in estimated glomerular filtration rate (eGFR) with adverse outcomes. Design \u2014","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/associations-between-modest-reductions-in-kidney-function-and-adverse-outcomes-in-young-adults\/","og_locale":"fr_FR","og_type":"article","og_title":"ICES | Associations between modest reductions in kidney function and adverse outcomes in young adults: retrospective, population based cohort study","og_description":"Objective \u2014 To study age specific associations of modest reductions in estimated glomerular filtration rate (eGFR) with adverse outcomes. Design \u2014","og_url":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/associations-between-modest-reductions-in-kidney-function-and-adverse-outcomes-in-young-adults\/","og_site_name":"ICES","article_publisher":"https:\/\/www.facebook.com\/ICESOntario\/","article_modified_time":"2023-07-24T19:52:42+00:00","og_image":[{"width":1200,"height":675,"url":"https:\/\/www.ices.on.ca\/wp-content\/uploads\/2024\/11\/ic-es-data-discovery-better-health-logo.jpg","type":"image\/jpeg"}],"twitter_card":"summary_large_image","schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/associations-between-modest-reductions-in-kidney-function-and-adverse-outcomes-in-young-adults\/","url":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/associations-between-modest-reductions-in-kidney-function-and-adverse-outcomes-in-young-adults\/","name":"ICES | Associations between modest reductions in kidney function and adverse outcomes in young adults: retrospective, population based cohort study","isPartOf":{"@id":"https:\/\/www.ices.on.ca\/fr\/#website"},"datePublished":"2023-06-23T12:15:58+00:00","dateModified":"2023-07-24T19:52:42+00:00","description":"Objective \u2014 To study age specific associations of modest reductions in estimated glomerular filtration rate (eGFR) with adverse outcomes. Design \u2014","breadcrumb":{"@id":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/associations-between-modest-reductions-in-kidney-function-and-adverse-outcomes-in-young-adults\/#breadcrumb"},"inLanguage":"fr-FR","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/associations-between-modest-reductions-in-kidney-function-and-adverse-outcomes-in-young-adults\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/associations-between-modest-reductions-in-kidney-function-and-adverse-outcomes-in-young-adults\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.ices.on.ca\/fr\/"},{"@type":"ListItem","position":2,"name":"Journal Articles","item":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/"},{"@type":"ListItem","position":3,"name":"Associations between modest reductions in kidney function and adverse outcomes in young adults: retrospective, population based cohort study"}]},{"@type":"WebSite","@id":"https:\/\/www.ices.on.ca\/fr\/#website","url":"https:\/\/www.ices.on.ca\/fr\/","name":"ICES","description":"POPULATION-BASED HEALTH RESEARCH THAT MAKES A DIFFERENCE","publisher":{"@id":"https:\/\/www.ices.on.ca\/fr\/#organization"},"alternateName":"Institute for Clinical Evaluative Sciences","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.ices.on.ca\/fr\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"fr-FR"},{"@type":"Organization","@id":"https:\/\/www.ices.on.ca\/fr\/#organization","name":"ICES","alternateName":"Institute for Clinical Evaluative Sciences","url":"https:\/\/www.ices.on.ca\/fr\/","logo":{"@type":"ImageObject","inLanguage":"fr-FR","@id":"https:\/\/www.ices.on.ca\/fr\/#\/schema\/logo\/image\/","url":"https:\/\/www.ices.on.ca\/wp-content\/uploads\/2023\/04\/ices-logo.png","contentUrl":"https:\/\/www.ices.on.ca\/wp-content\/uploads\/2023\/04\/ices-logo.png","width":"676","height":"618","caption":"ICES"},"image":{"@id":"https:\/\/www.ices.on.ca\/fr\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/ICESOntario\/","https:\/\/www.linkedin.com\/company\/ices-research-institute\/"]}]}},"_links":{"self":[{"href":"https:\/\/www.ices.on.ca\/fr\/wp-json\/wp\/v2\/journal_article\/16155","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ices.on.ca\/fr\/wp-json\/wp\/v2\/journal_article"}],"about":[{"href":"https:\/\/www.ices.on.ca\/fr\/wp-json\/wp\/v2\/types\/journal_article"}],"acf:post":[{"embeddable":true,"href":"https:\/\/www.ices.on.ca\/fr\/wp-json\/wp\/v2\/infographic\/16172"},{"embeddable":true,"href":"https:\/\/www.ices.on.ca\/fr\/wp-json\/wp\/v2\/news_release\/16174"},{"embeddable":true,"href":"https:\/\/www.ices.on.ca\/fr\/wp-json\/wp\/v2\/research_program\/6743"},{"embeddable":true,"href":"https:\/\/www.ices.on.ca\/fr\/wp-json\/wp\/v2\/site\/6734"},{"embeddable":true,"href":"https:\/\/www.ices.on.ca\/fr\/wp-json\/wp\/v2\/ices_scientist\/1264"},{"embeddable":true,"href":"https:\/\/www.ices.on.ca\/fr\/wp-json\/wp\/v2\/ices_scientist\/1144"},{"embeddable":true,"href":"https:\/\/www.ices.on.ca\/fr\/wp-json\/wp\/v2\/ices_scientist\/1107"}],"wp:attachment":[{"href":"https:\/\/www.ices.on.ca\/fr\/wp-json\/wp\/v2\/media?parent=16155"}],"wp:term":[{"taxonomy":"migration-helper-automated","embeddable":true,"href":"https:\/\/www.ices.on.ca\/fr\/wp-json\/wp\/v2\/migration-helper-automated?post=16155"},{"taxonomy":"migration-manual","embeddable":true,"href":"https:\/\/www.ices.on.ca\/fr\/wp-json\/wp\/v2\/migration-manual?post=16155"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/www.ices.on.ca\/fr\/wp-json\/wp\/v2\/topic?post=16155"},{"taxonomy":"migration-helper-qa-sample-set","embeddable":true,"href":"https:\/\/www.ices.on.ca\/fr\/wp-json\/wp\/v2\/migration-helper-qa-sample-set?post=16155"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}