{"id":1574,"date":"2014-09-16T00:00:00","date_gmt":"2014-09-16T04:00:00","guid":{"rendered":"https:\/\/icesontario.wpengine.com\/journal-articles\/who-essential-medicines-policies-and-use-in-developing-and-transitional-countries-an-analysis-of-reported-policy-implementation-and-medicines-use-surveys\/"},"modified":"2023-06-14T19:49:37","modified_gmt":"2023-06-14T23:49:37","slug":"who-essential-medicines-policies-and-use-in-developing-and-transitional-countries-an-analysis-of-reported-policy-implementation-and-medicines-use-surveys","status":"publish","type":"journal_article","link":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/who-essential-medicines-policies-and-use-in-developing-and-transitional-countries-an-analysis-of-reported-policy-implementation-and-medicines-use-surveys\/","title":{"rendered":"WHO essential medicines policies and use in developing and transitional countries: an analysis of reported policy implementation and medicines use surveys"},"content":{"rendered":"<p><strong>Background <\/strong>&#x2014; Suboptimal medicines use is a global public health problem. For 35 years the World Health Organization (WHO) has promoted essential medicines policies to improve quality use of medicines (QUM), but evidence of their effectiveness is lacking, and uptake by countries remains low. The objective was to determine whether WHO essential medicines policies are associated with better QUM. <\/p>\n<p><span class=\"bold\">Methods and Findings<\/span> &#x2014; The researchers&#xa0;compared results from independently conducted medicines use surveys in countries that did versus did not report implementation of WHO essential medicines policies.&#xa0;The researchers extracted survey data on ten validated QUM indicators and 36 self-reported policy implementation variables from WHO databases for 2002&#x2013;2008. The researchers calculated the average difference (as percent) for the QUM indicators between countries reporting versus not reporting implementation of specific policies. Policies associated with positive effects were included in a regression of a composite QUM score on total numbers of implemented policies. Data were available for 56 countries. Twenty-seven policies were associated with better use of at least two percentage points. Eighteen policies were associated with significantly better use (unadjusted p &lt; 0.05), of which four were associated with positive differences of 10% or more: undergraduate training of doctors in standard treatment guidelines, undergraduate training of nurses in standard treatment guidelines, the ministry of health having a unit promoting rational use of medicines, and provision of essential medicines free at point of care to all patients. In regression analyses national wealth was positively associated with the composite QUM score and the number of policies reported as being implemented in that country. There was a positive correlation between the number of policies (out of the 27 policies with an effect size of 2% or more) that countries reported implementing and the composite QUM score (r = 0.39, 95% CI 0.14 to 0.59, p = 0.003). This correlation weakened but remained significant after inclusion of national wealth in multiple linear regression analyses. Multiple policies were more strongly associated with the QUM score in the 28 countries with gross national income per capita below the median value (US&#x24;2,333) (r = 0.43, 95% CI 0.06 to 0.69, p = 0.023) than in the 28 countries with values above the median (r = 0.22, 95% CI &#x2212;0.15 to 0.56, p = 0.261). The main limitations of the study are the reliance on self-report of policy implementation and measures of medicines use from small surveys. While the data can be used to explore the association of essential medicines policies with medicines use, they cannot be used to compare or benchmark individual country performance. <\/p>\n<p><strong>Conclusions<\/strong> &#x2014; WHO essential medicines policies are associated with improved QUM, particularly in low-income countries. <\/p>\n","protected":false},"excerpt":{"rendered":"<p>Background &#x2014; Suboptimal medicines use is a global public health problem. For 35 years the World Health Organization (WHO) has promoted essential medicines policies to improve quality use of medicines (QUM), but evidence of their effectiveness is lacking, and uptake by countries remains low. The objective was to determine whether WHO essential medicines policies are [&hellip;]<\/p>\n","protected":false},"template":"","migration-helper-automated":[],"migration-manual":[],"topic":[60,35],"migration-helper-qa-sample-set":[],"class_list":["post-1574","journal_article","type-journal_article","status-publish","hentry","topic-policy-and-program-evaluation","topic-public-health"],"acf":{"citation":"Holloway KA, Henry D. <em>PLoS Med<\/em>. 2014; 11(9):e1001724. Epub 2014 Sep 16.","source_url":"http:\/\/journals.plos.org\/plosmedicine\/article?id=10.1371\/journal.pmed.1001724","ices_scientist":[1266],"site":[6733],"research_program":[6746],"news_release":[7321],"journal_article":[],"atlas":[],"research_report":[],"infographic":[],"video":[],"downloads":null,"links":null,"sitecore_item_id":"843ECB3C-296A-418F-A1D6-8F7A5617D2D2","sitecore_item_name":"WHO-essential-medicines-policies-and-use-in-developing-and-transitional-countries","sitecore_field_values":"{\n  \"__Valid from\": \"20170821T114505\",\n  \"Title\": \"WHO essential medicines policies and use in developing and transitional countries: an analysis of reported policy implementation and medicines use surveys\",\n  \"Short title\": \"WHO essential medicines policies\",\n  \"Summary\": \"The objective was to determine whether WHO essential medicines policies are associated with better QUM.\",\n  \"Citation\": \"<p>Holloway KA, Henry D. <em>PLoS Med<\/em>. 2014; 11(9):e1001724. Epub 2014 Sep 16.<\/p>\",\n  \"Abstract\": \"<p><strong>Background <\/strong>&mdash; Suboptimal medicines use is a global public health problem. For 35 years the World Health Organization (WHO) has promoted essential medicines policies to improve quality use of medicines (QUM), but evidence of their effectiveness is lacking, and uptake by countries remains low. The objective was to determine whether WHO essential medicines policies are associated with better QUM. <\/p>n<p><span class=\"bold\">Methods and Findings<\/span> &mdash; The researchers&nbsp;compared results from independently conducted medicines use surveys in countries that did versus did not report implementation of WHO essential medicines policies.&nbsp;The researchers extracted survey data on ten validated QUM indicators and 36 self-reported policy implementation variables from WHO databases for 2002&ndash;2008. The researchers calculated the average difference (as percent) for the QUM indicators between countries reporting versus not reporting implementation of specific policies. Policies associated with positive effects were included in a regression of a composite QUM score on total numbers of implemented policies. Data were available for 56 countries. Twenty-seven policies were associated with better use of at least two percentage points. Eighteen policies were associated with significantly better use (unadjusted p &lt; 0.05), of which four were associated with positive differences of 10% or more: undergraduate training of doctors in standard treatment guidelines, undergraduate training of nurses in standard treatment guidelines, the ministry of health having a unit promoting rational use of medicines, and provision of essential medicines free at point of care to all patients. In regression analyses national wealth was positively associated with the composite QUM score and the number of policies reported as being implemented in that country. There was a positive correlation between the number of policies (out of the 27 policies with an effect size of 2% or more) that countries reported implementing and the composite QUM score (r = 0.39, 95% CI 0.14 to 0.59, p = 0.003). This correlation weakened but remained significant after inclusion of national wealth in multiple linear regression analyses. Multiple policies were more strongly associated with the QUM score in the 28 countries with gross national income per capita below the median value (US$2,333) (r = 0.43, 95% CI 0.06 to 0.69, p = 0.023) than in the 28 countries with values above the median (r = 0.22, 95% CI &minus;0.15 to 0.56, p = 0.261). The main limitations of the study are the reliance on self-report of policy implementation and measures of medicines use from small surveys. While the data can be used to explore the association of essential medicines policies with medicines use, they cannot be used to compare or benchmark individual country performance. <\/p>n<p><strong>Conclusions<\/strong> &mdash; WHO essential medicines policies are associated with improved QUM, particularly in low-income countries. <\/p>n<p><a href=\"http:\/\/journals.plos.org\/plosmedicine\/article?id=10.1371\/journal.pmed.1001724\" title=\"opens external link\">View full text<\/a><\/p>\",\n  \"Keywords\": \"{2C5686FC-D177-4ED9-9BF1-F6D3DB6B3F95}|{128D8B1B-1143-4080-9185-2C8A3C4BDC30}\",\n  \"Related Products\": \"<h2>News release<\/h2>rn<h3><a href=\"~\/link.aspx?_id=B6895955BB094E2BAF38FBA22B169AD2&amp;_z=z\">Four simple \"essential medicines\" policies could save many lives<\/a><\/h3>\",\n  \"Research Programs\": \"{CFE36C89-C969-4C23-B5E4-1BA9E5BDC273}\",\n  \"ICES Locations\": \"{4FCAABBA-14A5-42E6-8F33-BC6C2F1D9908}\",\n  \"ICES Scientists\": \"{242795DE-E521-4AAA-A4DF-93AF84CC17CA}\",\n  \"Posted Date\": \"20140916T000000\",\n  \"Show on Publications Landing Page\": \"1\"\n}","previous_url":"https:\/\/www.ices.on.ca\/Publications\/Journal-Articles\/2014\/January\/WHO-essential-medicines-policies-and-use-in-developing-and-transitional-countries"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>ICES | WHO essential medicines policies and use in developing and transitional countries: an analysis of reported policy implementation and medicines use surveys<\/title>\n<meta name=\"description\" content=\"Background &#x2014; Suboptimal medicines use is a global public health problem. For 35 years the World Health Organization (WHO) has promoted essential\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/who-essential-medicines-policies-and-use-in-developing-and-transitional-countries-an-analysis-of-reported-policy-implementation-and-medicines-use-surveys\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"ICES | WHO essential medicines policies and use in developing and transitional countries: an analysis of reported policy implementation and medicines use surveys\" \/>\n<meta property=\"og:description\" content=\"Background &#x2014; Suboptimal medicines use is a global public health problem. 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