{"id":1562,"date":"2014-11-18T00:00:00","date_gmt":"2014-11-18T05:00:00","guid":{"rendered":"https:\/\/icesontario.wpengine.com\/journal-articles\/impact-of-legislation-and-a-prescription-monitoring-program-on-the-prevalence-of-potentially-inappropriate-prescriptions-for-monitored-drugs-a-time-series-analysis\/"},"modified":"2023-06-14T20:12:31","modified_gmt":"2023-06-15T00:12:31","slug":"impact-of-legislation-and-a-prescription-monitoring-program-on-the-prevalence-of-potentially-inappropriate-prescriptions-for-monitored-drugs-a-time-series-analysis","status":"publish","type":"journal_article","link":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/impact-of-legislation-and-a-prescription-monitoring-program-on-the-prevalence-of-potentially-inappropriate-prescriptions-for-monitored-drugs-a-time-series-analysis\/","title":{"rendered":"Impact of legislation and a prescription monitoring program on the prevalence of potentially inappropriate prescriptions for monitored drugs: a time series analysis"},"content":{"rendered":"<p><strong>Background<\/strong> &#x2014; The researchers&#xa0;assessed the impact of new legislation and a centralized prescription monitoring system (implemented November 2011 and May 2012, respectively), on the dispensing of prescriptions suggestive of misuse. <\/p>\n<p><strong>Methods<\/strong> &#x2014; The researchers conducted a time series analysis of publically-funded prescriptions for opioids, benzodiazepines and stimulants dispensed monthly from January 2007 to May 2013. In the primary analysis, a prescription was deemed potentially inappropriate if it was dispensed within 7 days of an earlier prescription for at least 30 tablets of a drug in the same class and originated from a different physician and different pharmacy. <\/p>\n<p><strong>Results<\/strong> &#x2014; The prevalence of potentially inappropriate opioid prescriptions decreased by 13.2% after enactment of the new legislation (from 1.59% in October 2011 to 1.38% in April 2012; p=0.01). No further significant change in trend was observed after the introduction of the narcotic monitoring system (NMS) (p=0.78). By May 2013, the prevalence had dropped to 0.95%. Inappropriate benzodiazepine prescribing was significantly influenced by both the legislation (p&lt;0.001) and the NMS (p=0.05), which together reduced potentially inappropriate prescribing by 57.5% between October 2011 and the end of the study period (from 0.40% to 0.17%). The prevalence of potentially inappropriate prescribing of stimulants was significantly influenced by the introduction of the NMS, falling from 0.68% in April 2012 to 0.27% in May 2013, following introduction of the NMS (p=0.02). <\/p>\n<p><strong>Interpretation<\/strong> &#x2014; For a select group of drugs prone to misuse and diversion, legislation and implementation of a prescription monitoring program dramatically reduced the prevalence of prescriptions highly suggestive of misuse.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Background &#x2014; The researchers&#xa0;assessed the impact of new legislation and a centralized prescription monitoring system (implemented November 2011 and May 2012, respectively), on the dispensing of prescriptions suggestive of misuse. Methods &#x2014; The researchers conducted a time series analysis of publically-funded prescriptions for opioids, benzodiazepines and stimulants dispensed monthly from January 2007 to May 2013. [&hellip;]<\/p>\n","protected":false},"template":"","migration-helper-automated":[],"migration-manual":[],"topic":[34,56,60],"migration-helper-qa-sample-set":[],"class_list":["post-1562","journal_article","type-journal_article","status-publish","hentry","topic-mental-health-and-addictions","topic-pharmacoepidemiology-and-drug-safety","topic-policy-and-program-evaluation"],"acf":{"citation":"Gomes T, Juurlink D, Yao Z, Camacho X, Paterson M, Singh S, Dhalla I, Sproule B, Mamdani M. <em>CMAJ Open<\/em>. 2014; 2(4):E256-61. Epub 2014 Oct 1.","source_url":"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4251507\/","ices_scientist":[1252,1282,1100,1213,1325],"site":[6733],"research_program":[6746],"news_release":[7296],"journal_article":[],"atlas":[],"research_report":[],"infographic":[],"video":[],"downloads":null,"links":null,"sitecore_item_id":"0675A273-3C37-499A-BD0D-F7330E1D9840","sitecore_item_name":"Impact-of-legislation-and-a-prescription-monitoring-program-on-the-prevalence","sitecore_field_values":"{\n  \"__Valid from\": \"20170818T123801\",\n  \"Title\": \"Impact of legislation and a prescription monitoring program on the prevalence of potentially inappropriate prescriptions for monitored drugs: a time series analysis\",\n  \"Short title\": \"Impact of legislation\",\n  \"Citation\": \"<p>Gomes T, Juurlink D, Yao Z, Camacho X, Paterson M, Singh S, Dhalla I, Sproule B, Mamdani M. <em>CMAJ Open<\/em>. 2014; 2(4):E256-61. Epub 2014 Oct 1.<\/p>\",\n  \"Abstract\": \"<p><strong>Background<\/strong> &mdash; The researchers&nbsp;assessed the impact of new legislation and a centralized prescription monitoring system (implemented November 2011 and May 2012, respectively), on the dispensing of prescriptions suggestive of misuse. <\/p>n<p><strong>Methods<\/strong> &mdash; The researchers conducted a time series analysis of publically-funded prescriptions for opioids, benzodiazepines and stimulants dispensed monthly from January 2007 to May 2013. In the primary analysis, a prescription was deemed potentially inappropriate if it was dispensed within 7 days of an earlier prescription for at least 30 tablets of a drug in the same class and originated from a different physician and different pharmacy. <\/p>n<p><strong>Results<\/strong> &mdash; The prevalence of potentially inappropriate opioid prescriptions decreased by 13.2% after enactment of the new legislation (from 1.59% in October 2011 to 1.38% in April 2012; p=0.01). No further significant change in trend was observed after the introduction of the narcotic monitoring system (NMS) (p=0.78). By May 2013, the prevalence had dropped to 0.95%. Inappropriate benzodiazepine prescribing was significantly influenced by both the legislation (p&lt;0.001) and the NMS (p=0.05), which together reduced potentially inappropriate prescribing by 57.5% between October 2011 and the end of the study period (from 0.40% to 0.17%). The prevalence of potentially inappropriate prescribing of stimulants was significantly influenced by the introduction of the NMS, falling from 0.68% in April 2012 to 0.27% in May 2013, following introduction of the NMS (p=0.02). <\/p>n<p><strong>Interpretation<\/strong> &mdash; For a select group of drugs prone to misuse and diversion, legislation and implementation of a prescription monitoring program dramatically reduced the prevalence of prescriptions highly suggestive of misuse.<\/p>n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4251507\/\" title=\"opens external link\">View full text<\/a><\/p>\",\n  \"Keywords\": \"{84FE2CDF-5B86-4CD1-A954-9886D022974F}|{95F4B009-565A-4BD9-8A5A-8652FBCAD504}|{B1D64275-8EBE-4BA1-83CB-D395C4CE0E93}\",\n  \"Related Products\": \"ntt<h2>News release <\/h2>n<h3><a href=\"~\/link.aspx?_id=E77F25F548444C4CB05950AF52223EFE&amp;_z=z\">nLegislation significantly decreased potentially inappropriate drug prescriptions n<\/a><\/h3>\",\n  \"Research Programs\": \"{CFE36C89-C969-4C23-B5E4-1BA9E5BDC273}\",\n  \"ICES Locations\": \"{4FCAABBA-14A5-42E6-8F33-BC6C2F1D9908}\",\n  \"ICES Scientists\": \"{1FA4634A-81DF-4A25-8739-98ABF3872B45}|{5268F1B0-EB3E-4577-93DF-3C70C9399847}|{4A1034A0-5248-46A2-805E-20FBC57B1237}|{C3A1DE68-838D-4F81-AA49-35368583A9A8}|{F2F916BC-2EE9-4C65-BCAB-086ED6BB971A}\",\n  \"Posted Date\": \"20141118T111200\",\n  \"Show on Publications Landing Page\": \"1\"\n}","previous_url":"https:\/\/www.ices.on.ca\/Publications\/Journal-Articles\/2014\/January\/Impact-of-legislation-and-a-prescription-monitoring-program-on-the-prevalence"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>ICES | Impact of legislation and a prescription monitoring program on the prevalence of potentially inappropriate prescriptions for monitored drugs: a time series analysis<\/title>\n<meta name=\"description\" content=\"Background &#x2014; 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