{"id":13237,"date":"2023-02-14T00:00:00","date_gmt":"2023-02-14T05:00:00","guid":{"rendered":"https:\/\/icesontario.wpengine.com\/publications\/journal-articles\/outcomes-following-coronary-artery-bypass-grafting-with-multiple-arterial-grafting-by-pump-status-in-men-and-women\/"},"modified":"2023-07-21T13:14:19","modified_gmt":"2023-07-21T17:14:19","slug":"outcomes-following-coronary-artery-bypass-grafting-with-multiple-arterial-grafting-by-pump-status-in-men-and-women","status":"publish","type":"journal_article","link":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/outcomes-following-coronary-artery-bypass-grafting-with-multiple-arterial-grafting-by-pump-status-in-men-and-women\/","title":{"rendered":"Outcomes following coronary artery bypass grafting with multiple arterial grafting by pump status in men and women"},"content":{"rendered":"<p><strong>Objective<\/strong> \u2014 Multiple arterial grafting (MAG) and off-pump surgery are two strategies proposed to improve outcomes with coronary artery bypass grafting (CABG). To determine the impact of off-pump surgery on outcomes after CABG with MAG in men and women.<\/p>\n<p><strong>Methods<\/strong> \u2014 This cohort study used population-based data to identify all Ontarians undergoing isolated CABG with MAG between October 2008 and September 2019. The primary outcome was all-cause mortality. Secondary outcomes included major adverse cardiac and cerebrovascular events (MACCE) (hospitalization for stroke, myocardial infarction hospitalization or heart failure, or repeat revascularization). Analysis used propensity-score overlap-weighted cause-specific Cox proportional hazard regression.<\/p>\n<p><strong>Results<\/strong> \u2014 2,989 women (1,188 off-pump, 1,801 on-pump) and 16,209 men (6,065 off-pump, 10,144 on-pump) underwent MAG with a median follow-up of 5.0 (IQR: 2.7-8.0) years. Compared to the on-pump approach, all-cause mortality was not changed with off-pump status (hazard ratio [HR] in women: 1.25 [95% CI 0.83, 1.88]; in men: 1.08 [0.85, 1.37]). In women, MACCE risk was significantly higher off-pump (HR 1.45 [1.04-2.03]) with non-significant increased risks observed for all component outcomes.<\/p>\n<p><strong>Conclusion<\/strong> \u2014 In patients undergoing CABG with MAG, this population-based analysis found no association between pump status and survival in either men or women. However, it did suggest that off-pump MAG in women may be associated with an increased risk of MACCE.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Objective \u2014 Multiple arterial grafting (MAG) and off-pump surgery are two strategies proposed to improve outcomes with coronary artery bypass grafting (CABG). To determine the impact of off-pump surgery on outcomes after CABG with MAG in men and women. Methods \u2014 This cohort study used population-based data to identify all Ontarians undergoing isolated CABG with [&hellip;]<\/p>\n","protected":false},"template":"","migration-helper-automated":[],"migration-manual":[],"topic":[40,25],"migration-helper-qa-sample-set":[],"class_list":["post-13237","journal_article","type-journal_article","status-publish","hentry","topic-cardiovascular-disease","topic-surgery"],"acf":{"citation":"Rubens FD, Fremes SE, Grubic N, Fergusson D, Taljaard M, van Walraven C. <em>J Thorac Cardiovasc Surg<\/em>. 2023; Feb 14 [Epub ahead of print].","source_url":"https:\/\/doi.org\/10.1016\/j.jtcvs.2023.02.008","ices_scientist":[1119],"site":[6734],"research_program":[6742],"news_release":"","journal_article":"","atlas":"","research_report":"","infographic":"","video":"","downloads":null,"links":null,"sitecore_item_id":"50811D66-3041-4C1F-9A41-DE47F9C55D18","sitecore_item_name":"Outcomes-following-coronary-artery-bypass-grafting-with-multiple-arterial-grafting","sitecore_field_values":"{\r\n  \"Title\": \"Outcomes following coronary artery bypass grafting with multiple arterial grafting by pump status in men and women\",\r\n  \"Short title\": \"Outcomes following coronary artery\",\r\n  \"Summary\": \"The study aim was to determine the impact of off-pump surgery on outcomes after coronary artery bypass grafting with multiple arterial grafting in men and women.\",\r\n  \"Citation\": \"<p>Rubens FD, Fremes SE, Grubic N, Fergusson D, Taljaard M, van Walraven C. <em>J Thorac Cardiovasc Surg<\/em>. 2023; Feb 14 [Epub ahead of print]. DOI: <a href=\"https:\/\/doi.org\/10.1016\/j.jtcvs.2023.02.008\" title=\"opens external link\">https:\/\/doi.org\/10.1016\/j.jtcvs.2023.02.008<\/a><\/p>\",\r\n  \"Abstract\": \"<p><strong>Objective<\/strong> &mdash; Multiple arterial grafting (MAG) and off-pump surgery are two strategies proposed to improve outcomes with coronary artery bypass grafting (CABG). To determine the impact of off-pump surgery on outcomes after CABG with MAG in men and women.<\/p>n<p><strong>Methods<\/strong> &mdash; This cohort study used population-based data to identify all Ontarians undergoing isolated CABG with MAG between October 2008 and September 2019. The primary outcome was all-cause mortality. Secondary outcomes included major adverse cardiac and cerebrovascular events (MACCE) (hospitalization for stroke, myocardial infarction hospitalization or heart failure, or repeat revascularization). Analysis used propensity-score overlap-weighted cause-specific Cox proportional hazard regression.<\/p>n<p><strong>Results<\/strong> &mdash; 2,989 women (1,188 off-pump, 1,801 on-pump) and 16,209 men (6,065 off-pump, 10,144 on-pump) underwent MAG with a median follow-up of 5.0 (IQR: 2.7-8.0) years. Compared to the on-pump approach, all-cause mortality was not changed with off-pump status (hazard ratio [HR] in women: 1.25 [95% CI 0.83, 1.88]; in men: 1.08 [0.85, 1.37]). In women, MACCE risk was significantly higher off-pump (HR 1.45 [1.04-2.03]) with non-significant increased risks observed for all component outcomes.<\/p>n<p><strong>Conclusion<\/strong> &mdash; In patients undergoing CABG with MAG, this population-based analysis found no association between pump status and survival in either men or women. However, it did suggest that off-pump MAG in women may be associated with an increased risk of MACCE.<\/p>\",\r\n  \"ICES Scientists\": \"{372EE381-9B1A-49F5-AC1B-0D8675558A8D}\",\r\n  \"Posted Date\": \"20230214T000000\",\r\n  \"Show on Publications Landing Page\": \"1\"\r\n}","previous_url":"https:\/\/www.ices.on.ca\/Publications\/Journal-Articles\/2023\/February\/Outcomes-following-coronary-artery-bypass-grafting-with-multiple-arterial-grafting"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>ICES | Outcomes following coronary artery bypass grafting with multiple arterial grafting by pump status in men and women<\/title>\n<meta name=\"description\" content=\"Objective \u2014 Multiple arterial grafting (MAG) and off-pump surgery are two strategies proposed to improve outcomes with coronary artery bypass grafting\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, 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