{"id":13230,"date":"2023-03-07T00:00:00","date_gmt":"2023-03-07T05:00:00","guid":{"rendered":"https:\/\/icesontario.wpengine.com\/publications\/journal-articles\/endometriosis-and-cardiovascular-disease-a-population-based-cohort-study\/"},"modified":"2023-07-21T14:15:34","modified_gmt":"2023-07-21T18:15:34","slug":"endometriosis-and-cardiovascular-disease","status":"publish","type":"journal_article","link":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/endometriosis-and-cardiovascular-disease\/","title":{"rendered":"Endometriosis and cardiovascular disease: a population-based cohort study"},"content":{"rendered":"<p><strong>Background<\/strong> \u2014 Endometriosis, a prevalent condition among females of reproductive age, may be associated with increased risk of cardiovascular disease (CVD) through chronic inflammation and early menopause. The objective of this study was to estimate the association between endometriosis and subsequent risk of CVD.<\/p>\n<p><strong><br \/>\nMethods<\/strong> \u2014 We conducted a population-based cohort study using administrative health data from Ontario residents from 1993 to 2015. We compared the incidence of CVD and cardiovascular health outcomes between females with endometriosis and 2 age-matched females without endometriosis. The primary outcome was hospital admission for CVD. Secondary outcomes included in-hospital CVD events of interest and emergency department visits for CVD. We used Cox proportional hazards models to estimate adjusted hazard ratios (HRs) between endometriosis and CVD events.<\/p>\n<p><strong><br \/>\nResults<\/strong> \u2014 We identified 166 835 eligible patients with endometriosis and matched 333 706 patients without endometriosis. The mean age of those with endometriosis was 36.4 years. Patients with endometriosis had a higher incidence of hospital admission for CVD (195 admissions\/100 000 person-years) compared with those without endometriosis (163 admissions\/100 000 person-years). Similarly, the incidence of secondary CVD events was slightly higher among patients with endometriosis (292 cases\/100 000 person-years) than among those without endometriosis (224 cases\/100 000 person-years). Females with endometriosis had an increased risk of hospital admission (adjusted HR 1.14, 95% confidence interval [CI] 1.10\u20131.19) and secondary CVD events (adjusted HR 1.26, 95% CI 1.23\u20131.30).<\/p>\n<p><strong><br \/>\nInterpretation<\/strong> \u2014 In this large, population-based study, endometriosis was associated with a small increased risk of CVD events.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Background \u2014 Endometriosis, a prevalent condition among females of reproductive age, may be associated with increased risk of cardiovascular disease (CVD) through chronic inflammation and early menopause. The objective of this study was to estimate the association between endometriosis and subsequent risk of CVD. Methods \u2014 We conducted a population-based cohort study using administrative health [&hellip;]<\/p>\n","protected":false},"template":"","migration-helper-automated":[],"migration-manual":[],"topic":[40,46,21],"migration-helper-qa-sample-set":[],"class_list":["post-13230","journal_article","type-journal_article","status-publish","hentry","topic-cardiovascular-disease","topic-internal-medicine","topic-women-or-gender-based-research"],"acf":{"citation":"Blom JN, Velez MP, McClintock C, Shellenberger J, Pudwell J, Brogly SB, Bougie O. <em>CMAJ Open. <\/em>2023; 10(4):E227-36. Epub 2023 Mar 7.","source_url":"https:\/\/www.cmajopen.ca\/content\/11\/2\/E227","ices_scientist":[1168,23085],"site":[6736],"research_program":[6740],"news_release":[13264],"journal_article":"","atlas":"","research_report":"","infographic":"","video":"","downloads":null,"links":null,"sitecore_item_id":"49014B3B-F2B6-480C-BA4B-CBFFE2BD545A","sitecore_item_name":"Endometriosis-and-cardiovascular-disease-a-population-based-cohort-study","sitecore_field_values":"{\r\n  \"Title\": \"Endometriosis and cardiovascular disease: a population-based cohort study\",\r\n  \"Short title\": \"Endometriosis and cardiovascular\",\r\n  \"Summary\": \"The objective of this study was to estimate the association between endometriosis and subsequent risk of cardiovascular disease.\",\r\n  \"Citation\": \"<p>Blom JN, Velez MP, McClintock C, Shellenberger J, Pudwell J, Brogly SB, Bougie O. <em>CMAJ Open. <\/em>2023; 10(4):E227-36. Epub 2023 Mar 7. DOI: <a href=\"https:\/\/doi.org\/10.9778\/cmajo.20220144\" title=\"opens external link\">https:\/\/doi.org\/10.9778\/cmajo.20220144<\/a><\/p>\",\r\n  \"Abstract\": \"<p><strong>Background<\/strong> &mdash; Endometriosis, a prevalent condition among females of reproductive age, may be associated with increased risk of cardiovascular disease (CVD) through chronic inflammation and early menopause. The objective of this study was to estimate the association between endometriosis and subsequent risk of CVD.<\/p>n<p><strong>nMethods<\/strong> &mdash; We conducted a population-based cohort study using administrative health data from Ontario residents from 1993 to 2015. We compared the incidence of CVD and cardiovascular health outcomes between females with endometriosis and 2 age-matched females without endometriosis. The primary outcome was hospital admission for CVD. Secondary outcomes included in-hospital CVD events of interest and emergency department visits for CVD. We used Cox proportional hazards models to estimate adjusted hazard ratios (HRs) between endometriosis and CVD events.<\/p>n<p><strong>nResults<\/strong> &mdash; We identified 166 835 eligible patients with endometriosis and matched 333 706 patients without endometriosis. The mean age of those with endometriosis was 36.4 years. Patients with endometriosis had a higher incidence of hospital admission for CVD (195 admissions\/100 000 person-years) compared with those without endometriosis (163 admissions\/100 000 person-years). Similarly, the incidence of secondary CVD events was slightly higher among patients with endometriosis (292 cases\/100 000 person-years) than among those without endometriosis (224 cases\/100 000 person-years). Females with endometriosis had an increased risk of hospital admission (adjusted HR 1.14, 95% confidence interval [CI] 1.10&ndash;1.19) and secondary CVD events (adjusted HR 1.26, 95% CI 1.23&ndash;1.30).<\/p>n<p><strong>nInterpretation<\/strong> &mdash; In this large, population-based study, endometriosis was associated with a small increased risk of CVD events.<\/p>n<p><a href=\"https:\/\/www.cmajopen.ca\/content\/11\/2\/E227\" title=\"opens external link\">View full text<\/a><\/p>\",\r\n  \"ICES Scientists\": \"{64579365-C01D-4F5C-81E8-7A5ECC8B20D3}\",\r\n  \"Posted Date\": \"20230307T000000\",\r\n  \"Show on Publications Landing Page\": \"1\"\r\n}","previous_url":"https:\/\/www.ices.on.ca\/Publications\/Journal-Articles\/2023\/March\/Endometriosis-and-cardiovascular-disease-a-population-based-cohort-study"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>ICES | Endometriosis and 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