{"id":13182,"date":"2023-04-04T00:00:00","date_gmt":"2023-04-04T04:00:00","guid":{"rendered":"https:\/\/icesontario.wpengine.com\/publications\/journal-articles\/treatment-patterns-and-outcomes-in-adolescents-and-young-adults-with-nodular-lymphocyte-predominant-hodgkin-lymphoma-an-impact-cohort-study\/"},"modified":"2023-07-24T13:54:16","modified_gmt":"2023-07-24T17:54:16","slug":"treatment-patterns-and-outcomes-in-adolescents-and-young-adults-with-nodular-lymphocyte-predominant-hodgkin-lymphoma-an-impact-cohort-study","status":"publish","type":"journal_article","link":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/treatment-patterns-and-outcomes-in-adolescents-and-young-adults-with-nodular-lymphocyte-predominant-hodgkin-lymphoma-an-impact-cohort-study\/","title":{"rendered":"Treatment patterns and outcomes in adolescents and young adults with nodular lymphocyte-predominant Hodgkin lymphoma: an IMPACT cohort study"},"content":{"rendered":"<p>We leveraged population-based clinical and healthcare data to identify treatment patterns and long-term outcomes among adolescents and young adults (AYA) with nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL). All Ontario, Canada, AYA aged 15-21 years at diagnosis with NLPHL between 1992 and 2012 were identified, and their detailed clinical data were collected. Linkage to healthcare databases identified additional events (subsequent malignant neoplasms [SMN], relapses and deaths). Event-free survival (EFS) and overall survival (OS) were compared by locus of care (adult vs. paediatric) and predictors of outcomes determined. Of 1014 AYA with Hodgkin lymphoma, 54 (5.3%) had NLPHL; 15 (27.8%) were treated at a paediatric centre. No paediatric centre patient received radiation only versus 16 (41.0%) of adult centre patients. Excision only was more common in paediatric centres (<em>p<\/em> &lt; 0.001). The 20-year EFS and OS rates were 82.9% \u00b1 5.2% and 100% respectively. Advanced stage (hazard ratio: 4.9, 95% CI: 1.3-18.4; <em>p<\/em> = 0.02) was associated with inferior EFS. Although the 25-year cumulative incidence of SMN was 19.3% \u00b1 9.6% for the entire cohort, there were no SMN among the patients treated with excision only. AYA with NLPHL have outstanding long-term survival. Resection alone was rare outside of paediatric institutions but associated with excellent outcomes. Given substantial SMN risks, chemotherapy-sparing and radiation-sparing strategies for appropriate subsets of patients are warranted.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>We leveraged population-based clinical and healthcare data to identify treatment patterns and long-term outcomes among adolescents and young adults (AYA) with nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL). All Ontario, Canada, AYA aged 15-21 years at diagnosis with NLPHL between 1992 and 2012 were identified, and their detailed clinical data were collected. Linkage to healthcare databases identified [&hellip;]<\/p>\n","protected":false},"template":"","migration-helper-automated":[],"migration-manual":[],"topic":[38,16],"migration-helper-qa-sample-set":[],"class_list":["post-13182","journal_article","type-journal_article","status-publish","hentry","topic-cancer-and-cancer-screening","topic-children-and-young-people"],"acf":{"citation":"Punnett A, Baxter NN, Hodgson D, Sutradhar R, Pole JD, Lau C, Nathan PC, Gupta S. <em>Br J Haematol<\/em>. 2023; Apr 4 [Epub ahead of print].","source_url":"https:\/\/doi.org\/10.1111\/bjh.18757","ices_scientist":[1177,1261,1370,1098,1239,1302],"site":[6733],"research_program":[6741],"news_release":"","journal_article":"","atlas":"","research_report":"","infographic":"","video":"","downloads":null,"links":null,"sitecore_item_id":"6A8B7697-0281-4675-BE6D-63FFCB355493","sitecore_item_name":"Treatment-patterns-and-outcomes-in-adolescents-and-young-adults-with-nodular-lymphocyte","sitecore_field_values":"{\r\n  \"Title\": \"Treatment patterns and outcomes in adolescents and young adults with nodular lymphocyte-predominant Hodgkin lymphoma: an IMPACT cohort study\",\r\n  \"Short title\": \"Treatment patterns and outcomes in\",\r\n  \"Summary\": \"This study found that given substantial subsequent malignant neoplasms risks, chemotherapy-sparing and radiation-sparing strategies for appropriate subsets of patients are warranted.\",\r\n  \"Citation\": \"<p>Punnett A, Baxter NN, Hodgson D, Sutradhar R, Pole JD, Lau C, Nathan PC, Gupta S. <em>Br J Haematol<\/em>. 2023; Apr 4 [Epub ahead of print]. DOI: <a href=\"https:\/\/doi.org\/10.1111\/bjh.18757\" title=\"opens external link\">https:\/\/doi.org\/10.1111\/bjh.18757<\/a><\/p>\",\r\n  \"Abstract\": \"<p>We leveraged population-based clinical and healthcare data to identify treatment patterns and long-term outcomes among adolescents and young adults (AYA) with nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL). All Ontario, Canada, AYA aged 15-21 years at diagnosis with NLPHL between 1992 and 2012 were identified, and their detailed clinical data were collected. Linkage to healthcare databases identified additional events (subsequent malignant neoplasms [SMN], relapses and deaths). Event-free survival (EFS) and overall survival (OS) were compared by locus of care (adult vs. paediatric) and predictors of outcomes determined. Of 1014 AYA with Hodgkin lymphoma, 54 (5.3%) had NLPHL; 15 (27.8%) were treated at a paediatric centre. No paediatric centre patient received radiation only versus 16 (41.0%) of adult centre patients. Excision only was more common in paediatric centres (<em>p<\/em> &lt; 0.001). The 20-year EFS and OS rates were 82.9% &plusmn; 5.2% and 100% respectively. Advanced stage (hazard ratio: 4.9, 95% CI: 1.3-18.4; <em>p<\/em> = 0.02) was associated with inferior EFS. Although the 25-year cumulative incidence of SMN was 19.3% &plusmn; 9.6% for the entire cohort, there were no SMN among the patients treated with excision only. AYA with NLPHL have outstanding long-term survival. Resection alone was rare outside of paediatric institutions but associated with excellent outcomes. Given substantial SMN risks, chemotherapy-sparing and radiation-sparing strategies for appropriate subsets of patients are warranted.<\/p>\",\r\n  \"ICES Scientists\": \"{73B9FD95-5453-4FBA-B02E-CD2911B86ACD}|{0FDA1DFE-97C3-41FE-AD90-6966265DC178}|{56BF24FA-D81E-4114-BF1F-4715A424E26C}|{F5F3AB6E-CD96-4F14-BDD6-206C43AC2DD3}|{92701820-E853-436C-8AD9-173545BA0A7D}|{26914DE7-C67E-4326-AAFE-E0BC7A893323}\",\r\n  \"Posted Date\": \"20230404T000000\",\r\n  \"Show on Publications Landing Page\": \"1\"\r\n}","previous_url":"https:\/\/www.ices.on.ca\/Publications\/Journal-Articles\/2023\/April\/Treatment-patterns-and-outcomes-in-adolescents-and-young-adults-with-nodular-lymphocyte"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.0 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>ICES | Treatment patterns and outcomes in adolescents and young adults with nodular lymphocyte-predominant Hodgkin lymphoma: an IMPACT cohort study<\/title>\n<meta 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