{"id":13156,"date":"2023-03-07T00:00:00","date_gmt":"2023-03-07T05:00:00","guid":{"rendered":"https:\/\/icesontario.wpengine.com\/publications\/journal-articles\/effectiveness-of-mrna-covid-19-vaccine-booster-doses-against-omicron-severe-outcomes\/"},"modified":"2023-07-21T14:28:42","modified_gmt":"2023-07-21T18:28:42","slug":"effectiveness-of-mrna-covid-19-vaccine-booster-doses-against-omicron-severe-outcomes","status":"publish","type":"journal_article","link":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/effectiveness-of-mrna-covid-19-vaccine-booster-doses-against-omicron-severe-outcomes\/","title":{"rendered":"Effectiveness of mRNA COVID-19 vaccine booster doses against Omicron severe outcomes"},"content":{"rendered":"

We estimated the effectiveness of booster doses of monovalent mRNA COVID-19 vaccines against Omicron-associated severe outcomes among adults in Ontario, Canada. We used a test-negative design to estimate vaccine effectiveness (VE) against hospitalization or death among SARS-CoV-2-tested adults aged \u226550 years from January 2 to October 1, 2022, stratified by age and time since vaccination. We also compared VE during BA.1\/BA.2 and BA.4\/BA.5 sublineage predominance. We included 11,160 cases and 62,880 tests for test-negative controls. Depending on the age group, compared to unvaccinated adults, VE was 91-98% 7-59 days after a third dose, waned to 76-87% after \u2265240 days, was restored to 92-97% 7-59 days after a fourth dose, and waned to 86-89% after \u2265120 days. VE was lower and declined faster during BA.4\/BA.5 versus BA.1\/BA.2 predominance, particularly after \u2265120 days. Here we show that booster doses of monovalent mRNA COVID-19 vaccines restored strong protection against severe outcomes for at least 3 months after vaccination. Across the entire study period, protection declined slightly over time, but waned more during BA.4\/BA.5 predominance.<\/p>\n","protected":false},"excerpt":{"rendered":"

We estimated the effectiveness of booster doses of monovalent mRNA COVID-19 vaccines against Omicron-associated severe outcomes among adults in Ontario, Canada. We used a test-negative design to estimate vaccine effectiveness (VE) against hospitalization or death among SARS-CoV-2-tested adults aged \u226550 years from January 2 to October 1, 2022, stratified by age and time since vaccination. […]<\/p>\n","protected":false},"template":"","migration-helper-automated":[],"migration-manual":[],"topic":[39,35],"migration-helper-qa-sample-set":[],"class_list":["post-13156","journal_article","type-journal_article","status-publish","hentry","topic-infectious-diseases","topic-public-health"],"acf":{"citation":"Grewal R, Nguyen L, Buchan SA, Wilson SE, Nasreen S, Austin PC, Brown KA, Fell DB, Gubbay JB, Schwartz KL, Tadrous M, Wilson K, Kwong JC. Nat Commun<\/em>. 2023; 14(1):1273. Epub 2023 Mar 7.","source_url":"https:\/\/www.nature.com\/articles\/s41467-023-36566-1","ices_scientist":[1161,1149,1126,1385,1181,1347,1108,16240],"site":[6733],"research_program":[6745],"news_release":"","journal_article":"","atlas":"","research_report":"","infographic":"","video":"","downloads":null,"links":null,"sitecore_item_id":"E7880973-8FD0-42F6-8897-3083EA02C26E","sitecore_item_name":"Effectiveness-of-mRNA-COVID-19-vaccine-booster-doses-against-Omicron-severe-outcomes","sitecore_field_values":"{\r\n \"Title\": \"Effectiveness of mRNA COVID-19 vaccine booster doses against Omicron severe outcomes\",\r\n \"Short title\": \"Effectiveness of mRNA COVID-19\",\r\n \"Summary\": \"The study showed that booster doses of monovalent mRNA COVID-19 vaccines restored strong protection against severe outcomes for at least 3 months after vaccination.\",\r\n \"Citation\": \"

Grewal R, Nguyen L, Buchan SA, Wilson SE, Nasreen S, Austin PC, Brown KA, Fell DB, Gubbay JB, Schwartz KL, Tadrous M, Wilson K, Kwong JC. Nat Commun<\/em>. 2023; 14(1):1273. Epub 2023 Mar 7. DOI: https:\/\/doi.org\/10.1038\/s41467-023-36566-1<\/a><\/p>\",\r\n \"Abstract\": \"

We estimated the effectiveness of booster doses of monovalent mRNA COVID-19 vaccines against Omicron-associated severe outcomes among adults in Ontario, Canada. We used a test-negative design to estimate vaccine effectiveness (VE) against hospitalization or death among SARS-CoV-2-tested adults aged ≥50 years from January 2 to October 1, 2022, stratified by age and time since vaccination. We also compared VE during BA.1\/BA.2 and BA.4\/BA.5 sublineage predominance. We included 11,160 cases and 62,880 tests for test-negative controls. Depending on the age group, compared to unvaccinated adults, VE was 91-98% 7-59 days after a third dose, waned to 76-87% after ≥240 days, was restored to 92-97% 7-59 days after a fourth dose, and waned to 86-89% after ≥120 days. VE was lower and declined faster during BA.4\/BA.5 versus BA.1\/BA.2 predominance, particularly after ≥120 days. Here we show that booster doses of monovalent mRNA COVID-19 vaccines restored strong protection against severe outcomes for at least 3 months after vaccination. Across the entire study period, protection declined slightly over time, but waned more during BA.4\/BA.5 predominance.<\/p>n

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