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Publication Results (145)

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  • Risk factors for posterior compared to anterior ischemic stroke: an observational study of the Registry of the Canadian Stroke Network

    Subramanian G, Silva J, Silver FL, Fang J, Kapral MK, Oczkowski W, Gould L, O'Donnell MJ; Investigators of the Registry of the Canadian Stroke Network. Neuroepidemiology. 2009; 33(1):12-6. Epub 2009 Mar 20.

  • The relationship between cardiologist care and clinical outcomes in patients with new-onset atrial fibrillation

    Singh SM, Qiu F, Webster L, Austin PC, Ko DT, Tu JV, Wijeysundera HC. Can J Cardiol. 2017; 33(12):1693-700.

  • December 2017

    • Supply of Ontario physicians providing comprehensive care lower than thought
    • Highlighting our data partnership with Immigration, Refugees and Citizenship Canada: A population-based study of postpartum mental health service use by immigrant women in Ontario, Canada
    • Highlighting our data partnership with Immigration, Refugees and Citizenship Canada: Impact of immigration status on cancer outcomes in Ontario, Canada
    ICES research video series
    • Laura Rosella on creating a new population risk tool for predicting high-cost users of health care
    ICES in the News
    • Cardiovascular and neuropsychiatric events following varenicline use for smoking cessation
    • Financial incentives did not increase psychiatric follow-up care
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    • The role of mental health and addiction among high-cost patients: a population-based study
    • Association of atrial fibrillation and oral anticoagulant use with perioperative outcomes after major noncardiac surgery
    • Melanoma patterns of care in Ontario: a call for a strategic alignment of multidisciplinary care
    • The relationship between cardiologist care and clinical outcomes in patients with new-onset atrial fibrillation
    • Population-based study to determine the health system costs of using the 21-gene assay
    • Perioperative chemotherapy for bladder cancer in the general population: Are practice patterns finally changing?
    • Does access to end-of-life homecare nursing differ by province and community size? 
    • Using newborn screening analytes to identify cases of neonatal sepsis
  • Association of early-stage breast cancer and subsequent chemotherapy with risk of atrial fibrillation

    Abdel-Qadir H, Thavendiranathan P, Fung K, Amir E, Austin PC, Anderson GS, Lee DS. JAMA Netw Open. 2019; 2(9):e1911838. Epub 2019 Sep 20. DOI: 10.1001/jamanetworkopen.2019.11838.

  • Trends in anticoagulant use at nursing home admission and variation by frailty and chronic kidney disease among older adults with atrial fibrillation

    Campitelli MA, Bronskill SE, Huang A, Maclagan LC, Atzema CL, Hogan DB, Lapane KL, Harris DA, Maxwell CJ. Drugs Aging. 2021; 38(7):611-23. Epub 2021 Apr 21. DOI:

  • Evaluation of the risk of stroke without anticoagulation therapy in men and women with atrial fibrillation aged 66 to 74 years without other CHA2DS2-VASc factors

    Abdel-Qadir H, Singh SM, Pang A, Austin PC, Jackevicius CA, Tu K, Dorian P, Ko DT. JAMA Cardiol. 2021; 6(8):918-25. Epub 2021 May 19, 2021. DOI:

  • March 2017

    • Use of medications of questionable benefit at the end of life in nursing home residents with advanced dementia
    • Risk of firearm injuries among children and youth of immigrant families
    • Early non-persistence with dabigatran and rivaroxaban in patients with atrial fibrillation
    Research video
    • Moira Kapral on risks of swallowing problems after stroke
    ICES in the News
    • Relationship between cardiac rehabilitation participation and health service expenditures within a universal health care system
    • Association of the timing of pregnancy with survival in women with breast cancer
    • Socioeconomic gradients in all-cause, premature and avoidable mortality among immigrants and long-term residents  
    • Failure of fertility therapy and subsequent adverse cardiovascular events
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    • Association between cardiovascular risk factors and aortic stenosis: the CANHEART aortic stenosis study
    • Infants born to opioid-dependent women in Ontario, 2002-2014
    • Mortality and costs of patients with community-onset Clostridium difficile infection identified using ED visits and hospital admissions
    • The relationship between therapeutic self-care and adverse events for home care clients in Ontario, Canada
    • Impact of unrestricted access to pregabalin on the use of opioids and other CNS-active medications
  • August 2017

    • Prolonged standing on the job more likely to lead to heart attack than prolonged sitting
    • Antipsychotics common for adults with intellectual and developmental disabilities
    ICES Research Video Series
    • Rinku Sutradhar on opioid use in long-term cancer survivors
    ICES in the News
    • 1 in 5 opioid-related deaths in Ontario involve alcohol
    • Toward Quality Mental Health Services in Canada: a comparison of performance indicators across five provinces
    • Behind the prescriptions: A snapshot of opioid use across all Ontarians
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    • Predictors of obtaining follow-up care in the province of Ontario, Canada, following a new diagnosis of atrial fibrillation, heart failure, and hypertension in the emergency department
    • The variation of statin use among nursing home residents and physicians: a cross-sectional analysis
    • Cost-effectiveness analysis of potentially curative and combination treatments for hepatocellular carcinoma with person-level data in a Canadian setting
    • Lithium use, but not valproate use, is associated with a higher risk of chronic kidney disease in older adults with mental illness
    • A cross-sectional population-based study of breast cancer screening among women with HIV in Ontario, Canada
    • Association between operator specialty and outcomes after carotid artery revascularization
    • Costs of health care across primary care models in Ontario
  • January 2018

    Call for abstracts: IPDLN 2018 Conference
    • Diabetes risk in childhood cancer survivors: a population-based study
    • Association between handover of anesthesia care and adverse postoperative outcomes among patients undergoing major surgery
      ICES in the News
      • Acute myocardial infarction after laboratory-confirmed influenza infection
      • Effect of air quality alerts on human health: a regression discontinuity analysis in Toronto, Canada
      ICES Top 17 of '17
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      • Temporal trends in mental health service utilization across outpatient and acute care sectors: a population-based study from 2006 to 2014
      • The economic burden of cancer care in Canada: a population-based cost study
      • Elevated incidence of atrial fibrillation and stroke in patients with atrial flutter – a population-based study
      • The relation between food insecurity and mental health care service utilization in Ontario
      • Intergenerational abortion tendency between mothers and teenage daughters: population based cohort study
      • The impact of diabetes on breast cancer treatments and outcomes: a population-based study
      • Predictors of specialized pediatric palliative care involvement and impact on patterns of end-of-life care in children with cancer
    • September 2018

      • Initial cholinesterase inhibitor therapy dose and serious events in older women and men
      • Traumatic brain injury as an independent risk factor for problem gambling: a matched case-control study
        ICES in the News
        • Landscape of Prescription Stimulant Use
        • Emergency department use and enrollment in a medical home providing after-hours care
        • Identification and management of frailty in the primary care setting
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        • Are we making a difference in primary care for adults with intellectual and developmental disabilities?
        • Antipsychotic drug dispensing in older adults with parkinsonism
        • Low-dose trazodone, benzodiazepines and fall-related injuries in nursing homes: a matched-cohort study
        • Variation in the health outcomes associated with frailty among home care clients: relevance of caregiver distress and client sex
        • Trends in mental health service utilisation in immigrant youth in Ontario, Canada, 1996–2012: a population-based longitudinal cohort study
        • Sleep apnea increases the risk of new hospitalized atrial fibrillation: a historical cohort study
      • October 2019

        • Influenza vaccine effectiveness in preventing hospitalizations in older patients with chronic obstructive pulmonary disease
        • Association between physician intensity of antibiotic prescribing and the prescription of benzodiazepines, opioids and proton-pump inhibitors to nursing home residents: a population-based observational study
        • Cardiovascular consequences of obstructive sleep apnea in women: a historical cohort study
        ICES in the News
        • Prevalence of inappropriateness of parenteral vitamin B12 administration in Ontario, Canada
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        • One-year home-time and mortality after thrombolysis compared with nontreated patients in a propensity-matched analysis
        • Prescription synthetic oral cannabinoid use among older adults with chronic obstructive pulmonary disease: a population-based cohort study
        • Time trends in opioid prescribing among Ontario long-term care residents: a repeated cross-sectional study
        • Association of early-stage breast cancer and subsequent chemotherapy with risk of atrial fibrillation
        • An opioid prescription for men undergoing minor urologic surgery is associated with an increased risk of new persistent opioid use
        • Emergency department use in people who experience imprisonment in Ontario, Canada
        • Data variability across Canadian administrative health databases: differences in content, coding, and completeness
      • February 2022

        • ICES Research Forum – Save the Date
        • Utilization of physician-based mental health care services among children and adolescents before and during the COVID-19 pandemic in Ontario, Canada
        • The association between recreational cannabis legalization, commercialization and cannabis attributable emergency department visits in Ontario, Canada: an interrupted time-series analysis
        ICES in the News
        • Incident cancer detection during the COVID-19 pandemic
        • Impact of team-based care on emergency department use
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        • COVID-19 excess mortality among long-term care residents in Ontario, Canada
        • The rate of unnecessary interventions for the management of knee osteoarthritis: a population-based cohort study
        • Trends in non-receipt of recommended chronic obstructive pulmonary disease medication
        • Association between handover of anesthesiology care and 1-year mortality among adults undergoing cardiac surgery
        • Practice profiles and patterns of Ontario family medicine residents 5 years after residency examinations: an exploratory study
        • Drug overdoses during the COVID-19 pandemic among recently homeless individuals
        • Prevalence, cost, and variation in cost of pediatric hospitalizations in Ontario, Canada
        • Association of diabetes duration and glycemic control with stroke rate in patients with atrial fibrillation and diabetes: a population-based cohort study
      • How reliable are administrative data for capturing stroke patients and their care?

        Porter J, Mondor L, Kapral MK, Fang J, Hall RE. Cerebrovasc Dis Extra. 2016; 6(3):96-106. Epub 2016 Oct 18.

      • Using phase-based costing of real-world data to inform decision-analytic models for atrial fibrillation

        Tawfik A, Wodchis WP, Pechlivanoglou P, Hoch J, Husereau D, Krahn M. Appl Health Econ Health Policy. 2016; 14(3):313-22. Epub 2016 Feb 29.

      • Development and validation of a prognostic tool for direct enteral tube insertion after acute stroke

        Joundi RA, Saposnik G, Martino R, Fang J, Kapral MK. Stroke. 2020; 51(6):1720-6. Epub 2020 May 13. DOI:

      • Cardiovascular risk associated with ibrutinib use in chronic lymphocytic leukemia: a population-based cohort study

        Abdel-Qadir H, Sabrie N, Leong D, Pang A, Austin PC, Prica A, Nanthakumar K, Calvillo-Argüelles O, Lee DS, Thavendiranathan P. J Clin Oncol. 2021; 39(31):3453-62. Epub 2021 Aug 31. DOI:

      • Real world long-term outcomes among adults undergoing transcatheter patent foramen closure with amplatzer PFO occluder

        Abrahamyan L, Barker M, Dharma C, Lee DS, Austin PC, Asghar A, Muthuppalaniappan A, Benson L, Osten M, Horlick EM. Int J Cardiol. 2022; Sep 19 [Epub ahead of print]. DOI:

      • Age disparities in stroke quality of care and delivery of health services

        Saposnik G, Black SE, Hakim A, Fang J, Tu JV, Kapral MK; Investigators of the Registry of the Canadian Stroke Network (RCSN); Stroke Outcomes Research Canada (SORCan) Working Group. Stroke. 2009; 40(10):3328-35. Epub 2009 Aug 20.

      • CCORT/CCS quality indicators for congestive heart failure care

        Lee DS, Tran C, Flintoft V, Grant FC, Liu PP, Tu JV; Canadian Cardiovascular Outcomes Research Team/Canadian Cardiovascular Society Heart Failure Quality Indicator Panel. Can J Cardiol. 2003; 19(4):357-64.

      • Defibrillation testing at the time of ICD insertion: an analysis from the Ontario ICD Registry

        Healey JS, Birnie DH, Lee DS, Krahn AD, Crystal E, Simpson CS, Dorian P, Chen Z, Cameron D, Verma A, Connolly SJ, Gula LJ, Lockwood E, Nair G, Tu JV; Ontario ICD Database Investigators. J Cardiovasc Electrophysiol. 2010; 21(12):1344-8.

      • Care and outcomes in patients with ischemic stroke with and without preexisting dementia

        Saposnik G, Cote R, Rochon PA, Mamdani M, Liu Y, Raptis S, Kapral MK, Black SE; Registry of the Canadian Stroke Network; Stroke Outcome Research Canada (SORCan) Working Group. Neurology. 2011; 77(18):1664-73.

      • July 2017

        • Wide regional variation in Ontarians' access to family doctors
        • People living in rural households have lower risk of developing inflammatory bowel disease
        • Differences in growth of Canadian children compared to the WHO 2006 Child Growth Standards
        • Older and cheaper test for heart disease just as effective as newer tests
        ICES Research Video Series
        • Eva Grunfeld on primary care use during adjuvant chemotherapy for breast cancer
        ICES in the News
        • Electrocardiograms in low-risk patients undergoing an annual health examination
        • Long-term morbidity and mortality in patients without early complications after stroke or transient ischemic attack
        • Patterns of physician prescribing for opioid maintenance treatment in Ontario, Canada in 2014
        • The effect of changes in cervical cancer screening guidelines on chlamydia testing
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        • Outcomes associated with a pediatric clinical diabetes network in Ontario: a population-based time-trend analysis
        • TA population-based study of homicide deaths in Ontario, Canada using linked death records
        • Severe maternal morbidity associated with maternal birthplace: a population-based register study
        • Association of proteinuria and incident atrial fibrillation in patients with intact and reduced kidney function
        • A retrospective assessment of prognostication in 456,685 patients undergoing elective major non-cardiac surgery
        • Emergency department flow measures for adult and pediatric patients in British Columbia and Ontario: a retrospective, repeated cross-sectional study
        • Estimating multimorbidity prevalence with the Canadian Chronic Disease Surveillance System
      • IScore: a risk score to predict death early after hospitalization for an acute ischemic stroke

        Saposnik G, Kapral MK, Liu Y, Hall R, O'Donnell M, Raptis S, Tu JV, Mamdani M, Austin PC; Investigators of the Registry of the Canadian Stroke Network; Stroke Outcomes Research Canada (SORCan) Working Group. Circulation. 2011; 123(7): 739-49. Epub 2011 Feb 7.

      • Discriminating clinical features of heart failure with preserved vs. reduced ejection fraction in the community

        Ho JE, Gona P, Pencina MJ, Tu JV, Austin PC, Vasan RS, Kannel WB, D'Agostino RB, Lee DS, Levy D. Eur Heart J. 2012; 33(14):1734-41. Epub 2012 Apr 16.

      • The PLAN Score: a bedside prediction rule for death and severe disability following acute ischemic stroke

        O'Donnell MJ, Fang J, D'Uva C, Saposnik G, Gould L, McGrath E, Kapral MK; Investigators of the Registry of the Canadian Stroke Network. Arch Intern Med. 2012; 172(20):1548-56.

      • Benchmarks for acute stroke care delivery

        Hall RE, Khan F, Bayley MT, Asllani E, Lindsay P, Hill MD, O'Callaghan C, Silver FL, Kapral MK. Int J Qual Health Care. 2013; 25(6):710-8. Epub 2013 Oct 17.

      • Risk factors for death or stroke after carotid endarterectomy: observations from the Ontario Carotid Endarterectomy Registry

        Tu JV, Wang H, Bowyer B, Green L, Fang J, Kucey D; Participants in the Ontario Carotid Endarterectomy Registry. Stroke. 2003; 34(11):2568-73. Epub 2003 Oct 2.

      • Risk of fractures after stroke: results from the Ontario Stroke Registry

        Kapral MK, Fang J, Alibhai SM, Cram PM, Cheung AM, Casaubon LK, Prager M, Stamplecoski M, Rashkovan B, Austin PC. Neurology. 2017; 88(1):57-64. Epub 2016 Nov 23.

      • Predicting survival in patients with heart failure with an implantable cardioverter defibrillator: the Heart Failure Meta-score

        Alba AC, Walter SD, Guyatt GH, Levy WC, Fang J, Ross HJ, Lee DS. J Card Fail. 2018; 24(11):735-45. Epub 2017 Nov 22.

      • Validation of algorithms to identify invasive electrophysiology procedures using administrative data in Ontario, Canada

        Singh SM, Webster L, Calzavara A, Wijeysundera HC. Med Care. 2017; 55(6):e44-50. Epub 2014 Nov 20.

      • September 2019

        • Risks of preoperative anemia in women undergoing elective hysterectomy and myomectomy
        • Sex-specific differences in end-of-life burdensome interventions and antibiotic therapy in nursing home residents with advanced dementia
        • Chronic physical conditions and risk for perinatal mental illness: a population-based retrospective cohort study
        • Physician availability in long-term care and resident hospital transfer: a retrospective cohort study
        ICES in the News
        • Population-based secular trends in lower extremity amputation for diabetes and peripheral artery disease
        • Opioid prescribing after surgery in the United States, Canada and Sweden
        • Sex differences in long‐term survival after major cardiac surgery: a population‐based cohort study
        • Trends in the use of cardiac imaging for patients with heart failure in Canada
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        • Days spent at home in the last 6 months of life: a quality indicator of end of life care in patients with hematologic malignancies
        • Trends in use of medical imaging in US health care systems and in Ontario, Canada, 2000-2016
        • Ambient air pollution and the risk of atrial fibrillation and stroke: a population-based cohort study
        • Incidence of hospitalizations and emergency department visits for herpes zoster in immunocompromised and immunocompetent adults in Ontario, Canada, 2002-2016
        • Understanding those overdue for cancer screening by five years or more: a retrospective cohort study in Ontario, Canada
        • Impact of the 2016 policy change on the delivery of Medscheck services in Ontario: an interrupted time-series analysis
        • The impact of hospital harm on length of stay, costs of care and length of person-centred episodes of care: a retrospective cohort study
      • January 2020

        Impact Stories
        • Surgical duration is associated with an increased risk of periprosthetic infection following total knee arthroplasty: a population-based retrospective cohort study
        • The risk of death within five years of first hospitalization in older adults
        • Determinants of direct discharge home from critical care units: a population-based cohort analysis
        • High-cost patients and preventable spending: a population-based study
        • Prescribing of oral anticoagulants in the emergency department and subsequent long-term use by older adults with atrial fibrillation
          ICES in the News
          • Neighbourhood-level marginalization and avoidable mortality in Ontario, Canada: a population-based study
          • Association of patient, prescriber, and region with the initiation of first prescription of biologic disease-modifying antirheumatic drug among older patients with rheumatoid arthritis and identical health insurance coverage
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          • Characterising risk of homicide in a population-based cohort
          • Association between hospital teaching status and outcomes after out-of-hospital cardiac arrest
          • The direct healthcare costs attributable to West Nile virus illness in Ontario, Canada: a population-based cohort study using laboratory and health administrative data
          • Resident trainees increase surgical time: a comparison of obstetric and gynaecologic procedures in academic versus community hospitals
          • Comparative effectiveness of fluoroquinolone antibiotic use in uncomplicated acute exacerbations of COPD: a multi-cohort study
          • Changes in opioid prescribing behaviors among family physicians who participated in a weekly tele-mentoring program
          • A new record linkage for assessing infant mortality rates in Ontario, Canada
        • Cardiovascular consequences of obstructive sleep apnea in women: a historical cohort study

          Kendzerska T, Leung R, Atzema C, Chandy G, Meteb M, Malhotra A, Hawker G, Gershon AS. Sleep Med. 2020; 68:71-9. Epub 2019 Sep 11. DOI: 10.1016/j.sleep.2019.08.021.

        • October 2020

          • Residential greenspace in childhood reduces risk of pediatric inflammatory bowel disease: a population-based cohort study
          • Estimated surge in hospital and intensive care admission because of the coronavirus disease 2019 pandemic in the Greater Toronto Area, Canada: a mathematical modelling study
          • Modest increase in fertility consultations in female adolescents and young adults with lymphoma: a population-based study
          ICES in the News
          • Firearm-related injuries and deaths in Ontario, Canada, 2002-2016: a population-based study
          • Morbidity and mortality associated with prescription cannabinoid drug use in COPD
          • Medication discontinuation in adults with chronic obstructive pulmonary disease discharged from hospital: a population-based cohort study
          • Association between exposure to general versus regional anesthesia and risk of dementia in older adults
          • COVID-19 in long-term care homes in Ontario and British Columbia
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          • Drug utilization in Ontario during the COVID-19 pandemic
          • Heterogeneity in testing, diagnosis and outcome in SARS-CoV-2 infection across outbreak settings in the Greater Toronto Area, Canada: an observational study
          • Levothyroxine dose and risk of atrial fibrillation: a nested case-control study
          • Are anticholinergic medications used for overactive bladder associated with new onset depression? A population-based matched cohort study
          • Deconstructing the rise in mental health–related ED visits among children and youth in Ontario, Canada
          • One size does not fit all: diabetes prevalence among immigrants of the South Asian diaspora
          • Medical immunosuppression and outcomes in cutaneous melanoma: a population-based cohort study
          • Multiple arterial coronary bypass grafting is associated with greater survival in women
        • Temporal trends in the use of investigations after stroke or transient ischemic attack

          Ng VT, Bayoumi AM, Fang J, Burton KR, Stamplecoski M, Edwards JD, Kapral MK. Med Care. 2016; 54(5):430-4. Epub 2016 May 1.

        • Macrolides, digoxin toxicity and the risk of sudden death: a population-based study

          Quinn KL, Macdonald EM, Gomes T, Mamdani MM, Huang A, Juurlink DN; Canadian Drug Safety and Effectiveness Research Network (CDSERN). Drug Saf. 2017; 40(9):835-40. Epub 2017 Apr 18.

        • Association of direct oral anticoagulant-proton pump inhibitor cotherapy with adverse outcomes: protocol for a population-based cohort study

          Wang M, Paterson MJ, Thabane L, Siegal D, Mbuagbaw L, Targownik L, Holbrook A. BMJ Open. 2022; 12(6):e057991. Epub 2022 Jun 13. DOI:

        • Sex differences and similarities in the management and outcome of stroke patients

          Holroyd-Leduc JM, Kapral MK, Austin PC, Tu JV. Stroke. 2000; 31(8):1833-7.

        • Preoperative laboratory investigations: rates and variability prior to low-risk surgical procedures

          Kirkham KR, Wijeysundera DN, Pendrith C, Ng R, Tu JV, Boozary AS, Tepper J, Schull MJ, Levinson W, Bhatia RS. Anesthesiology. 2016; 124(4):804-14. Epub 2016 Jan 28.

        • Cardiac arrest in acute ischemic stroke: incidence, predisposing factors, and clinical outcomes

          Joundi RA, Rabinstein AA, Nikneshan D, Tu JV, Fang J, Holloway R, Saposnik G; Stroke Outcomes Research Working Group. J Stroke Cerebrovasc Dis. 2016; 25(7):1644-52. Epub 2016 Apr 7.