Fine particulate matter concentration and composition and the incidence of childhood asthma

Background — Several studies have found positive associations between outdoor fine particulate air pollution (≤2.5 μm, PM_2.5) and childhood asthma incidence. However, the impact of PM_2.5 composition on children’s respiratory health remains uncertain.

Objective — We examined whether joint exposure to PM_2.5 mass concentrations and its major chemical components was associated with childhood asthma development.

Methods — We conducted a population-based cohort study by identifying 1,130,855 singleton live births occurring between 2006 and 2014 in the province of Ontario, Canada. Concentrations of PM_2.5 and its seven major chemical components were assigned to participants based on their postal codes using chemical transport models and remote sensing. The joint impact of outdoor PM_2.5 concentrations and its major components and childhood asthma incidence (up to age 6) were estimated using Cox proportional hazards models, allowing for potential nonlinearity.

Results — We identified 167,080 children who developed asthma before age 6. In adjusted models, outdoor PM_2.5 mass concentrations during childhood were associated with increased incidence of childhood asthma (Hazard Ratio (HR) for each 1 μg/m3 increase = 1.026, 95% CI: 1.021–1.031). We found that the joint effects of PM_2.5 and its components on childhood asthma incidence may be 24% higher than the conventional approach. Specific components/source markers such as black carbon, ammonium, and nitrate appeared to play an important role.

Conclusions — Early life exposure to PM_2.5 and its chemical components is associated with an increased risk of asthma development in children. The heterogeneous nature of PM_2.5 should be considered in future health risk assessments.