Knowledge of the acute cardiovascular effects of cannabis consumption remains largely unknown, and is important given the changing landscape of legalization of recreational cannabis use. “4/20” is an annual event where many individuals gather to consume cannabis. An increased risk of adverse health events such as motor vehicle accidents have previously been reported to occur on “4/20”. In this study, population-based administrative databases in Ontario, Canada were used to evaluate the association between “4/20” and cardiovascular events. An increased risk of cardiovascular events on a population-level was not observed on “4/20”. Additional research into the changes in prevalence of use of cannabis with recreational legalization and acute and chronic risk with cannabis use is suggested.