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Do community demographics, environmental characteristics and access to care affect risks of developing ACOS and mortality in people with asthma?

To T, Zhu J, Carlsten C, Larsen K, Ryckman K, Feldman LY, Crighton E, Lougheed MD, Licskai C, Villeneuve PJ, Su Y, Sadatsafavi M, Gershon A. Eur Respir J. 2017; 50(3):1700644.


Individuals with asthma and chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS) have a more rapid decline in lung function, more frequent exacerbations and worse quality of life than those with asthma or COPD alone. Various risk factors may be associated with the development of ACOS, such as smoking history and status, obesity, comorbidity and indoor and outdoor environmental exposures. The risk of developing ACOS may vary substantially by region, since demographic and environmental risk factors and community characteristics are not geographically homogeneous. Here, we use population-based data to estimate the incidence of ACOS in the asthma population and to measure the association between demographic factors, community-level characteristics and environmental factors and the risk of incident ACOS and all-cause mortality while accounting for spatial autocorrelation.

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