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Risk of nontuberculous mycobacterial pulmonary disease with obstructive lung disease

Marras TK, Campitelli MA, Kwong JC, Lu H, Brode SK, Marchand-Austin A, Gershon AS, Jamieson FB. Eur Respir J. 2016; 48(3):928-31. Epub 2016 Jun 10.

Nontuberculous mycobacterial pulmonary disease (NTM-PD) is increasingly prevalent and especially common in the elderly. It is usually chronic, requiring complex therapy with suboptimal outcomes. Risk factors for NTM-PD may be covert, presumably disordered mucociliary defences, or overt structural lung abnormalities. In one study, 56% of NTM-PD patients had unexplained nontuberculous mycobacteria (NTM) and among the rest with structural lung disease, chronic obstructive pulmonary disease (COPD) was the most common predisposing condition.

Keywords: Chronic diseases and conditions Risk assessment Respiratory diseases