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Clinical consequences of generic warfarin substitution: an ecological study

Paterson JM, Mamdani M, Juurlink DN, Naglie G, Laupacis A, Stukel TA. JAMA. 2006; 296(16):1969-72.


Generic substitution policies are financially attractive.  Although several studies have found no clinically important effects of switching to generic warfarin formulations, some observational studies have found an increase in warfarin dosages or frequent and substantial changes in international normalized ratio (INR). Few studies have been sufficiently large to examine clinical outcomes, and none have done so in a large-population setting.

Keywords: Drug substitution Drugs (cardiovascular)

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