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Challenges of prescribing low-dose drug therapy for older people

Rochon PA, Clark JP, Gurwitz JH. CMAJ. 1999; 160(7):1029-31.


Elderly patients are at greater risk for adverse drug effects than younger people. Because most adverse effects are related to dose, conventional wisdom holds that drug therapy should be initiated at low doses. However, clinicians face several challenges when prescribing low-dose therapy for their older patients. This article presents three clinical scenarios to illustrate some of these challenges.

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Keywords: Drug therapy Geriatrics and aging

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